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CLINICAL BIOCHEMISTRY

CODE 80678
ACADEMIC YEAR 2017/2018
CREDITS 4 credits during the 2nd year of 9015 Molecular and health biology (LM-6) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR BIO/12
LANGUAGE Italian (English on demand)
TEACHING LOCATION GENOVA (Molecular and health biology)
SEMESTER 2° Semester
PREREQUISITES
Prerequisites
You can take the exam for this unit if you passed the following exam(s):
  • Molecular and health biology 9015 (coorte 2016/2017)
  • BIOLOGICAL CHEMISTRY 25727
  • HUMAN PHYSIOLOGY 61786
  • MOLECULAR BIOLOGY AND LABORATORY 65534

OVERVIEW

Clinical biochemistry studies the clinical significance of laboratory tests. During the course we will systematically address the study of laboratory medicine of the main organs and functions, which is a a key part of the diagnostic reasoning process.

AIMS AND CONTENT

LEARNING OUTCOMES

The aim of the clinical biochemistry part of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests of the “clinical chemistry profile” and of specific organs/functions. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests.

AIMS AND LEARNING OUTCOMES

The aim of the clinical biochemistry part of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests of the “clinical chemistry profile” and of specific organs/functions. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests.

TEACHING METHODS

plenary lectures.

A minimal attendance  to 70% of the plenary lectures is strongly recommended.

SYLLABUS/CONTENT

1-BLOOD

The complete blood count

Electrophoretic profile of serum proteins and its diagnostic interpretation

Principal serum enzymes of diagnostic interest

Non-protein nitrogen

Iron metabolism, quantitative and qualitative defects of hemoglobin

Electrolytes

2-LIVER FUNCTION

Enzymes, bilirubin and jaundice, modifications of serum proteins in selected liver diseases, coagulation factors, diagnosis of selected liver diseases

3-GLUCOSE METABOLISM

Hormones regulating glycemia

Causes of hyper- and hypo-glycemia

Lab tests in diabetes mellitus

Lab tests in chetoacidosis, glucose tolerance test, gestational diabetes.

4-LIPID METABOLISM

Lipoprotein classification and function

Reference values for blood lipids

Hyperlipidemic profiles and cardiovascular risk

5-URINE ANALYSIS AND TESTS OF RENAL FUNCTION

The physical-chemical urineanalysis

Renal functional tests: indicators of glomerular and tubular malfunction

6-TESTS FOR ENDOCRINE DISORDERS

Steroid, peptide and aminoacid-derived hormones: basal levels and pathologic conditions of hyper/hypo-secretion

Lab tests in the diagnosis of endocrinological disorders

7- LAB CONFIRMATION OF ACUTE MYOCARDIAL INFARCTION

8-TESTS OF PANCREATIC FUNCTION

9-ARTERIAL BLOOD GASES AND ACID-BASE BALANCE

10-VITAMINS

11-ELECTROLYTE BALANCE

RECOMMENDED READING/BIBLIOGRAPHY

online available slides (aula-web)

Common laboratory tests, Vaughn, Appleton&Lange

TEACHERS AND EXAM BOARD

Exam Board

ELENA ZOCCHI (President)

SANTINA BRUZZONE

LAURA STURLA

LESSONS

TEACHING METHODS

plenary lectures.

A minimal attendance  to 70% of the plenary lectures is strongly recommended.

LESSONS START

arranged with the students 

Class schedule

All class schedules are posted on the EasyAcademy portal.

EXAMS

EXAM DESCRIPTION

Knowledge acquired by the students will be verified with a written test.

ASSESSMENT METHODS

A multiple choice tests will ascertain whether the student will have acquired a sufficient knowledge ragarding the topics dealt with during the course.