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GENERAL PHYSIOPATHOLOGY

CODE 67362
ACADEMIC YEAR 2017/2018
CREDITS 8 credits during the 3nd year of 8745 MEDICINE AND SURGERY (LM-41) GENOVA
SCIENTIFIC DISCIPLINARY SECTOR MED/04
LANGUAGE Italian
TEACHING LOCATION GENOVA (MEDICINE AND SURGERY)
SEMESTER 1° Semester
PREREQUISITES
Prerequisites
You can take the exam for this unit if you passed the following exam(s):
  • MEDICINE AND SURGERY 8745 (coorte 2015/2016)
  • ETIOLOGY AND PATHOGENESIS OF DISEASES 72088
Prerequisites (for future units)
This unit is a prerequisite for:
  • MEDICINE AND SURGERY 8745 (coorte 2015/2016)
  • DERMATOLOGY, CLINICAL IMMUNOLOGY AND RHEUMATOLOGY 67377
  • CARDIOVASCULAR AND RESPIRATORY TRACT DISEASES 67384
  • PHARMACOLOGY I 67371
  • PHARMACOLOGY 80794
  • NEPHROLOGY AND ENDOCRINE METABOLIC DISEASES 67391
  • EYE, ORL AND DENTAL DISEASES 67407
  • GI TRACT DISEASES 67415
  • HAEMATOLOGY AND MEDICAL ONCOLOGY 67431
  • PATOLOGY 80811
  • INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY 67402

OVERVIEW

The course gives students the fundamental elements of pathophysiology, which are essential for the successive comprehension of clinical medical sciences.

AIMS AND CONTENT

LEARNING OUTCOMES

Physiopathology is a branch of medicine that combines physiology and pathology especially in the study of altered bodily function in disease. The learning outcome is the knowledge of the main physiopathological mechanisms of organs and systems,  in order to recognize the mechanisms and causes of their malfunction, and to be able to interpret the symptoms, which will be exposed to the students in the successive clinical courses

AIMS AND LEARNING OUTCOMES

Knowledge of the main physiopathological mechanisms of organs and systems, with particular regard to blood, liver, kidney, respiratory and digestive systems, some aspects of endocrinology and metabolism, and the physiopathology of neoplasms.

TEACHING METHODS

Lectures, with any possible dialectic interaction with students

SYLLABUS/CONTENT

Hematopoiesis, hematopoietic stem cell (HSC), mesenchimal stem cell (MSC), HSC transplant (HSCT).

Erythropoiesis, classification and examples of anemia: aplastic, paroxysmal nocturnal nemoglobinuria (PNH), immune hemolytic, deficiency (Fe, B12 and B9), drugs-mediated, secondary to chronic disorders.

Hemostasis and examples of hemostasis disorders (endothelium, platelets or coagulation factors abnormalities).

Oncology: benign and malign neoplasms, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Hematological malignances: classification and examples of myeloid and lymphoid neoplasms. Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment. Immune responses against cancer, tumor escape mechanisms, tumor-associated inflammation.

Pathogenesis and consequences of dyslipidemias. Atherosclerosis, cardiovascular diseases, Acute rheumatic fever (ARF), essential and secondary hypertension.

Classification of renal diseases, and acute and chronic renal failure. Hydro-electrolytic balance, in particular sodium and potassium. Acid base balance and its alterations.

Pathogenesis and pathophysiology of diabetes mellitus.

Pathophysiology of the respiratory system.

Pathophysiology of the liver and the biliary tract: acute and chronic hepatitis, cirrhosis and ascites, hepatic failure, portal hypertension, cholestasis, icterus, systemic effects of liver damage

Liver metabolic diseases: Alpha-1 antitrypsin deficiency
Hemochromatosis and Hemosiderosis
Wilson disease
Overview of most common digestive disorders
Overview of most common pancreatic  disorders

RECOMMENDED READING/BIBLIOGRAPHY

Robbins & Cotran Pathologic Basis of Disease, Elsevier

The didactic material is available in pdf format for download (https://www.aulaweb.unige.it). The aim of the course is also to familiarize students with online biomedical scientific literature (https://www.ncbi.nlm.nih.gov/pubmed)

TEACHERS AND EXAM BOARD

Exam Board

CRISTINA BOTTINO (President)

MARIA ADELAIDE PRONZATO (President)

NICOLA TRAVERSO (President)

ANNA MARIA BASSI

CINZIA MARIA DOMENICOTTI

LESSONS

TEACHING METHODS

Lectures, with any possible dialectic interaction with students

LESSONS START

1st semester, 3rd year

Class schedule

All class schedules are posted on the EasyAcademy portal.

EXAMS

EXAM DESCRIPTION

The students are evaluated in an oral examination. Two professors examine each student about any of the subject of the course program.

ASSESSMENT METHODS

The oral examination consists in several questions, starting from more general questions to more precise ones, in order to assess the knowledge of the students. Students must know the main physiopathological mechanisms of the selected organs/systems and demonstrate the ability to connect different subjects of the program.

Exam schedule

Date Time Location Type Notes
15/01/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
29/01/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
12/02/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
09/04/2018 09:00 GENOVA Orale APPELLO RISERVATO A STUDENTI FUORICORSO SENZA OBBLIGO DI FREQUENZA ORE 9, AULA PATOLOGIA GENERALE
04/06/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
18/06/2018 09:00 GENOVA Orale ORE 9, AULA FISIOLOGIA
09/07/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
10/09/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
24/09/2018 09:00 GENOVA Orale ORE 9, AULA PATOLOGIA GENERALE
12/11/2018 09:00 GENOVA Orale ore 9, Aula patologia generale Appello riservato a studenti fuoricorso o ripetenti SENZA OBBLIGO DI FREQUENZA

FURTHER INFORMATION

The didactic material is available in pdf format for download (https://www.aulaweb.unige.it)

Students can contact the teachers by mail  (information, appointment)