LEARNING OUTCOMES

The aim of this course is to provide the students with knowledge about fundamental concepts of the main pharmacological classes required to be able to administer the drugs commonly used during the odontoiatric practice, including their composition therapeutic effects and ADRs. Furthermore the student have to learn the effects, contraindications and adverse reactions of drugs prescribed to the patients that could interfere with his paractice and the knowledge of the drugs used in emergency.

AIMS AND LEARNING OUTCOMES

The main learning outcome of the Pharmacology course is acquisition of all the basic information required to be able to prescribe and administer the relevant drugs for the Odontoiatric practice, including mechanism of action, therapeutic indications, ADRs, and contraindications.

In detail the student have to get knowledge on:

the molecular and cellular targets that mediate the drug therapeutic and adverse effects;

administration modality and the fate of the drugs within the body, inclding the mechanisms of drug distribution, metabolism amd elimination;

the mechanisms mediating the development of the adverse drug reactions and their toxic effects; the possible causes of hydiosyncratic and allergic reactions toward drugs, included principle of pharmacogenetics and of drug-drug interactions;

the criteria to select different molecules within the same pharmacological class, referring to their potential toxicity and individual features of the patient.

TEACHING METHODS

Teaching of pharmacology will be performed by frontal lessons

SYLLABUS/CONTENT

1) Introduction to the pharmacology

 Drug development at preclinical levle and the clinical trials

Pharmacognosy

2) Drug administration routes

Bioavailability

Drug adsorption

Distribution

Drug metabolism and its modulation

Drug excretion

3) Drug activity: agonism antagonism

Therapeutic index

Tolerance

4) Receptors and their functioning as mechanism of action of the drugs

5) Adverse drug reactions and mechanisms inducing the individual differences in the drug activity

6) Drug acting on the autonomic nervous system

7) Local anesthetics

8) NSAID

9) Glucocorticoids

10) Benzodiazepines

11) Basics of antibacterial therapy

12) Beta-lactamic antibiotics (penicillins, cephalosporins, etc)

13) Glycopeptides

14) Macrolides

15) Fluorochinolones and other secnond choice antibiotics

16) Aminoglucosides, tetracyclines, CAF

17) Antifungines

18) Antiviral drugs

19) Antiplatelets, anticoagulats, antihaemerragic drugs

20) Drugs affecting calcium metabolism

21) Antihistaminergic drugs

22) Drugs used in emergency

23) Drug prescription rules

RECOMMENDED READING/BIBLIOGRAPHY

1) Amico-Roxas M., Caputi A., Del Tacca M., Farmacologia in Odontoiatria, UTET

2) Katzung, Farmacologia, Piccin

All the slides used during the lessons will be made available to the students through aulaweb