| CODE | 62662 |
|---|---|
| ACADEMIC YEAR | 2018/2019 |
| CREDITS | 7 credits during the 2nd year of 8746 School of Dental Medicine (LM-46) GENOVA |
| SCIENTIFIC DISCIPLINARY SECTOR | MED/04 |
| LANGUAGE | Italian |
| TEACHING LOCATION | GENOVA (School of Dental Medicine) |
| SEMESTER | 2° Semester |
| TEACHING MATERIALS | AULAWEB |
Pathology is the study (logos) of suffering (pathos). It is a bridging discipline connecting basic science and clinical practice, and is devoted to the study of the structural and functional changes in cells, tissues and organs that underlie disease. Through molecular, microbiological, immunological and morphological studies, General Pathology investigates the different causes of disease and their pathogenic mechanisms to favor the development of effective therapies.
The learning outcome is the knowledge the main responses of tissues to injuries mediated by exogenous or endogenous agents.
Lectures, with any possible dialectic interaction with students
Environmental factors of disease: physical causes (radiation, temperature extremes and mechanical energy); chemical causes.
Mechanisms of xenobiotic biotransformation.
Cell pathology: adaptation (atrophy/hypertropy, metaplasy, neoplasy) and death (necrosis and apoptosis).
Innate immunity: cells and molecules, local and systemic inflammation, acute and chronic, histological variants of inflammation, tissue damage repair and regeneration.
Adaptive Immunity: generation, education and function of B and T lymphocytes
Type I hypersensitivity
Mention of immune system’s diseases (immunodeficiencies, autoimmunity and auto-inflammatory diseases)
Mention of Hematopoietic stem cells (HSC) and HSC transplants
Atherosclerosis and mention of cardiovascular disease and rheumatic fever
Oncology: benign and malign neoplasms, the abnormal metabolism of cancer cells, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment.
Immune responses against cancer, Natural killer cells, tumor escape mechanisms, tumor-associated inflammation.
Environmental causes of cancer: physical, chemical and biological carcinogenesis.
Optical microscope evaluation of pathologic tissues (different types of inflammation and cancer).
Robbins & Cotran Pathologic Basis of Disease, Elsevier
Abbas & Lichtman Cellular and Molecular Immunology, Elsevier
The didactic material is available in pdf format for download (https://www.aulaweb.unige.it).
Office hours: By appointment Email: Cristina.Bottino@unige.it
Office hours: By appointment by email: ricciarelli@medicina.unige.it
CRISTINA BOTTINO (President)
ROBERTA RICCIARELLI (President)
Lectures, with any possible dialectic interaction with students
2nd semester, 2nd year
All class schedules are posted on the EasyAcademy portal.
The students are evaluated in an oral examination. Two professors examine each student about any of the subject of the course program.
The oral examination consists in several questions, starting from more general questions to more precise ones, in order to assess the knowledge of the students. Students must know the requested pathogenetic mechanisms and demonstrate the ability to connect different subjects of the program.
| Date | Time | Location | Type | Notes |
|---|---|---|---|---|
| 08/01/2019 | 09:00 | GENOVA | Orale | ore 9 Aula 5 Polo Alberti |
| 22/01/2019 | 09:00 | GENOVA | Orale | ore 9, Aula Fisiologia Umana |
| 12/02/2019 | 09:00 | GENOVA | Orale | ore 9 Aula 5 Polo Alberti |
| 11/06/2019 | 09:00 | GENOVA | Orale | ore 9 Aula 5 Polo Alberti |
| 25/06/2019 | 09:00 | GENOVA | Orale | ore 9 Aula 5 Polo Alberti |
| 16/07/2019 | 09:00 | GENOVA | Orale | ore 9 Aula 5 Polo Alberti |
| 10/09/2019 | 09:00 | GENOVA | Orale | ore 9, Aula 6 polo Alberti |
| 24/09/2019 | 09:00 | GENOVA | Orale | ore 9 Aula 5 Polo Alberti |
The didactic material is available in pdf format for download (https://www.aulaweb.unige.it)
Students can contact the teachers by mail (information, appointment)