|SCIENTIFIC DISCIPLINARY SECTOR||BIO/12|
You can take the exam for this unit if you passed the following exam(s):
Clinical biochemistry studies the clinical significance of laboratory tests. During the course we will systematically address the study of laboratory medicine of the main organs and functions, which is a a key part of the diagnostic reasoning process.
"The course aims at providing the students basic knowledge on analytical and diagnostic instruments used today in clinical laboratory.
The aim of the clinical biochemistry part of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests of the “clinical chemistry profile” and of tests exploring the function of specific organs/tissues. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests and how their interpretation can guide the diagnostic process.
Knowledge of the basic principles of metabolic biochemistry is required.
During the lessons, frontal or video-recorded in presence and available on aulaweb, the "normal" values of the common laboratory tests will be discussed, their dynamic range together with their modifications under conditions of tissue or organ disease. Simple clinical cases will be discussed to exemplify how the results of laboratory tests can be used in a clinical reasoning to confirm or rule out a diagnostic hypothesis.
Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.
A minimal attendance to 70% of the plenary lectures is strongly recommended.
The complete blood count
Electrophoretic profile of serum proteins and its diagnostic interpretation
Principal serum enzymes of diagnostic interest
Iron metabolism, quantitative and qualitative defects of hemoglobin
Enzymes, bilirubin and jaundice, modifications of serum proteins in selected liver diseases, coagulation factors, diagnosis of selected liver diseases
Hormones regulating glycemia
Causes of hyper- and hypo-glycemia
Lab tests in diabetes mellitus
Lab tests in chetoacidosis, glucose tolerance test, gestational diabetes.
Lipoprotein classification and function
Reference values for blood lipids
Hyperlipidemic profiles and cardiovascular risk
5-URINE ANALYSIS AND TESTS OF RENAL FUNCTION
The physical-chemical urineanalysis
Renal functional tests: indicators of glomerular and tubular malfunction
6-TESTS FOR ENDOCRINE DISORDERS
Steroid, peptide and aminoacid-derived hormones: basal levels and pathologic conditions of hyper/hypo-secretion
Lab tests in the diagnosis of endocrinological disorders
7- LAB CONFIRMATION OF ACUTE MYOCARDIAL INFARCTION
8-TESTS OF PANCREATIC FUNCTION
9-ARTERIAL BLOOD GASES AND ACID-BASE BALANCE
online available slides (aula-web)
Common laboratory tests, Vaughn, Appleton&Lange
Office hours: upon appointment by e-mail (email@example.com) Office: DIMES, section Biochemistry, Viale Benedetto XV 1 tel 010-3538161
ELENA ZOCCHI (President)
the course starts in the second semester; starting date and schedule arranged with the students
Knowledge acquired by the students will be verified with a written, multiple choice test.
The tests aim at verifying whether the clinical significance of the clinical chemistry tests has been understood and whether the student can apply this information to confirm or rule out specific clinical hypotheses, the essence of a clinical reasoning.
Multiple choice tests will ascertain whether the student will have acquired a sufficient knowledge ragarding the topics dealt with during the course. The tests will encompass the normal range of clinical chemistry values, the degree to which an "abnormal" value is suggestive of disease and which tests are indicated for a speficic diagnostic hypothesis.