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THE CELL

CODE 72086
ACADEMIC YEAR 2021/2022
CREDITS
  • 7 cfu during the 1st year of 8745 MEDICINA E CHIRURGIA(LM-41) - GENOVA
  • LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • PREREQUISITES
    Prerequisites (for future units)
    This unit is a prerequisite for:
    • MEDICINE AND SURGERY 8745 (coorte 2021/2022)
    • THE TISSUES (HISTOLOGY AND EMBRYOLOGY) 58029
    MODULES This unit is composed by:
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The course aims at providing students with basic knowledge of the molecular mechanisms supporting the principal cell functions (from morphology and internal organization up to gene expression regulation, generation of differentiated cell lineages and genetic traits transmission). 

    AIMS AND CONTENT

    LEARNING OUTCOMES

    Aim of this course is to provide the students with the knowledge of the basic principles of Cell Biology and Genetics as well as the ability to understand and analyze biological problems. Students will be requested to get acquainted with cell morphology and functions at the structural, ultrastructural and molecular levels

    AIMS AND LEARNING OUTCOMES

    Aim of this course is to provide students with the knowledge of the mechanisms regulating transmission and expression of genetic information; the structure, the organization and the function of the cell, with particular reference to the eukaryotic cell; the cellular and molecular mechanisms regulating the proliferation and the differentiation of eukaryotic cells; the cellular and molecular mechanisms underlying the interaction of the eukaryotic cell with other cells; the genetic basis of development and evolution.

    TEACHING METHODS

    The course includes classroom teaching on topics of Cell and Molecular Biology and Genetics.

    SYLLABUS/CONTENT

    The course is divided in 5 main areas:

    1. Macromolecules and general biology – Topics to be developed: Basic structure and properties of nucleic acids, proteins, lipids and carbohydrates shall be presented with focus on chemical bonds and molecular structure and interactions to provide notions to understand the basic cell biology. Principles of classification of living organisms. Species  and speciation. Cell theory: prokaryotes eukaryotes, general organization and their genomes,  molecular evolution. phylogenetic trees.

     

    2. Citology – Topics to be developed: Cell morphology and structure of eucariotes. Biological membranes (models, chemical composition and functions), cell organelles (Golgi, endoplasmic reticulum, lisosomes, peroxisomes, mitochondria, nucleus), cytoskeleton (composition and functions of the different systems). 

    3. Gene expression - Topics to be developed:  Nucleic acids structure and functions, DNA duplication, transcription, translation, gene expression regulation.

    4. Cell proliferation - Topics to be developed:  Cell cycle and control mechanisms, mitosis, meiosis, gametogenesis, mechanisms and meaning of cell death (apoptosis and necrosis), mechanisms of cell differentiation and cell transformation.

    5. Basic genetics - Topics to be developed:  Genetic significance of meiosis and gametogenesis. Basic notions of  classical genetics. 

    RECOMMENDED READING/BIBLIOGRAPHY

    Alberts et al.; "L'essenziale di biologia molecolare della cellula"; Zanichelli Editori.

    -Becker et al.; "Il mondo della cellula"; Pearsons Eds.

    -Solomon et al.; "Biologia"; Edises

    -Karp et al.; "Biologia cellulare e molecolare"; Edises

    -Pollard et a.; "Biologia Cellulare"; Elsevier-Masson Eds.

    -Russell et al.; “Genetica, un approccio moelcolare”, Pearson 

    TEACHERS AND EXAM BOARD

    Exam Board

    ROBERTA CASTRICONI (President)

    PAOLA GHIORZO (President)

    EMANUELA MARCENARO (President)

    SIMONA SIVORI (President)

    SVEVA BOLLINI

    WILLIAM BRUNO

    LORENZA PASTORINO

    ROBERTA TASSO

    RODOLFO QUARTO (President and Coordinator of Integrated Course)

    LESSONS

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    Final test is based on a multiple choice test. Should COVID19 restrictions be continued, final tests shall be held orally in remote mode.

    ASSESSMENT METHODS

    Aim of the written test is to verify that students have acquired the learning outcomes.Passing of the written test is achieved with  a score of at least 18/30, and at least 6/10 for each single module.

    Exam schedule

    Date Time Location Type Notes
    19/01/2022 09:00 GENOVA Orale
    02/02/2022 09:00 GENOVA Orale
    16/02/2022 09:00 GENOVA Orale
    07/06/2022 09:00 GENOVA Orale
    22/06/2022 09:00 GENOVA Orale
    09/09/2022 09:00 GENOVA Orale
    19/01/2022 09:00 GENOVA Orale
    02/02/2022 09:00 GENOVA Orale
    16/02/2022 09:00 GENOVA Orale
    07/06/2022 09:00 GENOVA Orale
    22/06/2022 09:00 GENOVA Orale
    09/09/2022 09:00 GENOVA Orale