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ANALYSIS OF DRUGS I (LM FAR)

CODE 80318
ACADEMIC YEAR 2021/2022
CREDITS
  • 8 cfu during the 2nd year of 8452 FARMACIA (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR CHIM/08
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 2° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • Pharmacy 8452 (coorte 2020/2021)
    • GENERAL AND INORGANIC CHEMISTRY (PHAR)(MD) 55413
    Prerequisites (for future units)
    This unit is a prerequisite for:
    • Pharmacy 8452 (coorte 2020/2021)
    • ANALYSIS OF DRUGS II 80322
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The course deals with the pre-treatment and the quantitative determination of substances of pharmaceutical interest. It is developed with theoretical and practical lessons. The topics of the course are listed as follows.

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The course consists of  lectures and individual trainings in laboratory, aims to provide a basic understanding about the methods for the pre-treatment and the quantitative determination of compounds with medicinal use.

    AIMS AND LEARNING OUTCOMES

    The course allows to acquire theoretical and practical information regarding the main methods of quantitative analysis of drugs such as volumetric analysis, in particular in the areas of acid-base, complexometric, redox and precipitation titrations. Sample pretreatment and drug determination methods include instrumental analysis such as gas chromatography and HPLC. The laboratory activities concern the dosage of drugs and purification techniques of the sample.

    TEACHING METHODS

    The course is developed with theoretical and practical lessons. The frontal teaching could be also carried out remotely in telematic mode due to the health emergency by COVID19.

    SYLLABUS/CONTENT

    Theoretical topics

    Guidelines on laboratory safety and chemical use

    Introduction to the quantitative determination of compounds registered in FU XII Ed. and FE VIII Ed.

    Classification and selection of analitycal methods.  Chemical, apparatus and methods for the quantitative determination of compounds with medicinal uses. Calculation used in pharmaceutical analysis. Sampling, standardization and calibration.

    Techniques of preparing sample: filtration, extraction, distillation, chromatography

    Sample characterization

    Introduction to volumetric titrations in pharmaceutical analysis: chemical equilibria in volumetric analysis. Preparation of standard solutions.

    Quantitative determination and applications: neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, Diazotization Titration.

    Gascromatoraphy and HPLC. 

    Practical trainings

    Extraction with solvent, distillation in vacuo. TLC.

    Chromatographyc separation and analysis of a mixture of drugs. Quantitative determination of drugs by mean of neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations.

    RECOMMENDED READING/BIBLIOGRAPHY

    • Principi di Analisi Farmaceutica, Quarta Edizione - V. Cavrini e V. Andrisano, ESCULAPIO
    • Analisi Farmaceutica David G. Watson Edra 2014
    • Fondamenti di chimica analitica di Skoog e West, Terza Edizione - F. James Holler e Stanley R. Crouch, EDISES – ISBN 9788879598651
    • Analisi chimico farmaceutica - F. Savelli e O. Bruno - PICCIN

     

    TEACHERS AND EXAM BOARD

    Exam Board

    ELENA CICHERO (President)

    PAOLA FOSSA

    ANNA CARBONE (Substitute)

    FRANCESCA MUSUMECI (Substitute)

    MICHELE TONELLI (Substitute)

    LESSONS

    LESSONS START

    In the second semester

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    Oral test. Exams could be  carried out remotely in telematic mode due to the health emergency by COVID19.

    ASSESSMENT METHODS

    The examination includes an oral test and an evaluation of the experimental ability achieved by the student while attending to practical trainings in laboratory.

    Exam schedule

    Date Time Location Type Notes
    21/06/2022 09:00 GENOVA Orale
    08/07/2022 09:00 GENOVA Orale
    22/07/2022 09:00 GENOVA Orale
    02/09/2022 09:00 GENOVA Orale
    16/09/2022 09:00 GENOVA Orale
    27/01/2023 09:00 GENOVA Orale
    17/02/2023 09:00 GENOVA Orale