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TOXICOLOGICAL CHEMISTRY

CODE 80340
ACADEMIC YEAR 2021/2022
CREDITS
  • 12 cfu during the 4th year of 8452 FARMACIA (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR CHIM/08
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 2° Semester
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    AIMS AND LEARNING OUTCOMES

    Toxicological Chemistry introduction: chemistry of toxic substances with emphasis on their interactions with biological tissues and living systems.

    Basic principles of chemistry and organic chemistry useful to understand toxicological chemistry.

    Xenobiotics metabolism: phase I and phase II reactions.

    Examples of phase I reactions: oxidation, reduction, hydroxylation.

    Examples of phase II reactions: conjugation by glucuronides, conjugation by sulphate, conjugation by amino acids, conjugation by glutathione, acetylation, metylation.

    Short account of pharmacokinetics, pharmacodynamics, and pharmacogenomics.

    Interactions between molecules: covalent bond, ionic bond, hydrogen bond, pi-pi interaction, van der Waals interaction.

    Interaction between toxic compounds and biological targets: nicotinoid and neonicotinoid insecticides, pyrethroids, PAH, endocrine disruptors.

    Mechanisms of toxicity of organic and inorganic xenobiotics: heavy metals, inorganic compounds, organic compounds, drugs, alcaloids. 

    Toxicity of environmental ompounds.

    At the end of the course the student knows the basic concepts concerning the reactivity and the mechanism of action of toxic substances. In particular the student knows the most common xenobiotics from a toxicological chemistry point of view.

    TEACHING METHODS

    Slides are used for the lessons, students are expected to be able to extrapolate concepts autonomously.

    SYLLABUS/CONTENT

    Organic Chemistry is a pre-requisite.

    TEACHERS AND EXAM BOARD

    Exam Board

    PAOLA FOSSA (President)

    ANNA CARBONE

    ELENA CICHERO

    MICHELE TONELLI

    LESSONS

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    oral discussion on different topics discussed in the course.

    Exam schedule

    Date Time Location Type Notes
    21/04/2022 09:00 GENOVA Orale
    22/06/2022 09:00 GENOVA Orale
    06/07/2022 09:00 GENOVA Orale
    20/07/2022 09:00 GENOVA Orale
    14/09/2022 09:00 GENOVA Orale
    25/01/2023 09:00 GENOVA Orale
    15/02/2023 09:00 GENOVA Orale