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CHIMICA FARMACEUTICA APPLICATA (LM)

CODE 67617
ACADEMIC YEAR 2021/2022
CREDITS
  • 8 cfu during the 5th year of 8451 CHIMICA E TECNOLOGIA FARMACEUTICHE (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR CHIM/09
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 1° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • Pharmaceutical chemistry and technology 8451 (coorte 2017/2018)
    • GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401
    • MATHEMATICS (PCT)(MD) 55402
    • PHYSICS (PCT)(MD) 55404
    • PHYSICAL CHEMISTRY (MD) 60821
    • ORGANIC CHEMISTRY I (PCT)(MD) 60822
    • ORGANIC CHEMISTRY II (PCT)(MD) 60828
    • PHARMACEUTICAL TECHNOLOGY AND LAW I (PCT) 67569
    • MEDICINAL AND TOXICOLOGICAL CHEMISTRY I 80446
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    Applied Medicinal Chemistry is the discipline dealing with  all the technological, scientific and bureaucratic aspects indispensable in order to develop and launch on the pharmaceutical market a new drug. Therefore in this course all the strategies carried out by pharmaceutical companies to optimize safety and bioavailability of the new active ingredient are exhaustively treated.   

    AIMS AND CONTENT

    LEARNING OUTCOMES

    Providing students all the fundamental principles they need to join a team of researchers of pharmaceutical companies involved in the design and development of a new drug endowed with high therapeutic index.

    AIMS AND LEARNING OUTCOMES

    Providing students all the fundamental principles about drug discovery and development, INN and IUPAC nomenclature of organic drugs, preformulation and biopharmaceutics studies, drugs metabolism, drugs targeting and advances in pharmaceutical polymers.

    At the end of the Applied Medicinal Chemistry course, students will be able to:

    • describe the pharmaceutical industry organization

    • write the correct IUPAC name of an organic active pharmaceutical ingredient

    • link the correct International Nonproprietary Name to the therapeutic class of the active pharmaceutical ingredient

    • establish the best studies to define the chemical and physical properties of an active pharmaceutical ingredient

    • design the best chemical and/or formulation changes for an active pharmaceutical ingredient to optimize its bioavailability

    • identify the best strategies to improve the therapeutic index

    TEACHING METHODS

    Theoretical lessons may be held online and they are aimed at simplifying the comprehension of the pharmaceutical topics treated. In this context the teacher supports particular closer examination of those topics particularly difficult to understand for students. Before starting a new lesson, to facilitate students to learn several connected chapters, a brief summing up of the previous lesson is carried out. 

    SYLLABUS/CONTENT

    Drug Discovery and development

    INN and IUPAC nomenclature of organic drugs

    The development of new active ingredients

    Preformulation studies

    Biopharmaceutics

    Drugs metabolism

    Drugs targeting

    Macromolecules and pharmaceutics

    RECOMMENDED READING/BIBLIOGRAPHY

    A particular book to make reference to Applied Medicinal Chemistry doesn't exist. The 8 chapters of the course are composed by topics put together properly by the teacher and deriving from updated and reliable reviews in the field of applied medicinal chemistry. Each chapter is exaustively explained to students throughout the lessons and for every chapter comprehensive notes are available on Aulaweb.

    TEACHERS AND EXAM BOARD

    Exam Board

    GIANCARLO GROSSI (President)

    SARA BALDASSARI

    GABRIELE CAVIGLIOLI

    ELEONORA RUSSO

    CARLA VILLA

    GUENDALINA ZUCCARI

    LESSONS

    LESSONS START

    Classes usually  start every year around the 20th of September with a weekly engagement of 6 hours splitted among three lessons each lasting two hours.

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    The Applied Medicinal Chemistry exam may be taken online and it is divided into two parts: the first one about drugs IUPAC nomenclature is written and carried out during the course; the second one is oral and lasts about 45 minutes for each students. Questions deal with 5 topics chosen by the teacher among the subjects treated during the course.  

    ASSESSMENT METHODS

    Since Applied Medicinal Chemistry Course deals with topics about the chemistry and bioavailability of most successful drugs, teacher assesses student's ability to both explain clearly and write correctly chemical structures involved in the exam questions.

    Exam schedule

    Date Time Location Type Notes
    21/04/2022 09:00 GENOVA Orale
    22/06/2022 09:00 GENOVA Orale
    05/07/2022 09:00 GENOVA Orale
    22/07/2022 09:00 GENOVA Orale
    12/09/2022 09:00 GENOVA Orale
    23/01/2023 09:00 GENOVA Orale
    20/02/2023 09:00 GENOVA Orale

    FURTHER INFORMATION

    Throughout the course but also before exams, depending on student's request, the teacher is available to offer additional explanations about subjects discussed during the course and considered more difficult to learn by students.