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GENERAL PATHOLOGY

CODE 101082
ACADEMIC YEAR 2021/2022
CREDITS
  • 5 cfu during the 1st year of 9298 TECNICHE DELLA PREVENZIONE NELL'AMBIENTE E NEI LUOGH(L/SNT4) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR MED/04
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 2° Semester
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    AIMS AND LEARNING OUTCOMES

    The main aim of General Pathology teaching is to provide students with basic knowledge on the following topics: i) causes of human diseases, ii) cell and tissue damage,iii) tissue response to damage (inflammation and repair) and iv) neoplastic disease.

    At the end of the course, students will be able to classify the causes of human diseases; recognize the adaptation responses to damage; classify inflammatory processes; describe the atypia of the tumor cell; acquire basic medical terminology to describe the pathological processes taken into consideration.

    TEACHING METHODS

    The teaching is organized in frontal lessons for a total of 20 hours. Lessons are given by the teacher with the help of presentations that are made available to students on the web classroom. In periods of health emergency, lessons are held remotely using the TEAMS platform and are recorded by the teacher.

    SYLLABUS/CONTENT

    INTRODUCTION. Fields of interest of General Pathology. Homeostasis concept. Definition of morbid phenomenon, morbid process, morbid state and disease.

    GENERAL ETIOLOGY. Causes of human diseases. Intrinsic causes. Gene, genomic and chromosomal mutations. Notes on congenital malformations. Concept of aplasia, agenesis and hypoplasia. Embriopathies and fetopathies.

    Extrinsic causes of a physical nature. Radiation: classification based on nature (corpuscular and electromagnetic) and biological effect (ionizing and exciting). Direct and indirect effects of radiation. Extrinsic causes of a mechanical nature: trauma of superficial tissues. Trauma of the internal organs. Osteoarticular trauma. Concepts of regeneration and repair. Wound healing by first and second intention. Extrinsic causes of a thermal nature: burns and frostbite. Extrinsic chemical causes: alteration of pH (acids and bases), solvent action, denaturing action and toxic action. Defenses against poisons. Congenital and acquired defenses.

     

    CELLULAR PATHOLOGY. Cell damage and death: necrosis and apoptosis. Damage adaptation responses. Atrophy. Hypertrophy and hyperplasia. Notes on the alterations of differentiation: metaplasia, dysplasia and anaplasia. Vacuolar degeneration. Fat degeneration. Protein accumulations.

     

    INFLAMMATORY RESPONSE. Definition, causes, and phases of the inflammatory response. Classification of acute inflammations: serous, fibrinous, mucous, purulent, hemorrhagic, necrotic, allergic. Chronic inflammation: characters and cells of the chronic inflammatory infiltrate. Classification of chronic inflammations: interstitial and granulomatous. Immunological and non-immunological granulomas.

    CANCERS. Definition of neoplasia: concepts of autonomy, afinalism and progression. Morphological atypia, biochemical and behavioral atypia. Metastases: definition, ways of metastasis, concept of organotropism. Molecular basis of tumors: oncogenes and tumor suppressors. Causes of tumors. Concept of initiation and promotion. Physical and chemical carcinogenic agents. Viral carcinogenesis. Classification of tumors: classification by behavior (benign and malignant); classification by histogenesis (epithelial and connective tissue tumors); classification by gradation and staging (TNM system).

    RECOMMENDED READING/BIBLIOGRAPHY

    Rubin E. and Reisner HM Patologia Generale-L'essenziale -Ediz Piccin-Vol. 1

    G.M. Pontieri Patologia Generale, Edizioni Piccin

    Lecture notes will be available on Aulaweb.

    TEACHERS AND EXAM BOARD

    Exam Board

    FRANCESCO D'AGOSTINI (President)

    ANDREA DE MARIA (President)

    BARBARA MARENGO

    LUIGI ROBBIANO

    VINCENZO TROVATO

    CINZIA MARIA DOMENICOTTI (President and Coordinator of Integrated Course)

    LESSONS

    LESSONS START

    Lessons start in the second semester in early March.

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    The exam consists of an oral test. In periods of health emergency, exams are held remotely using the TEAMS platform.

    ASSESSMENT METHODS

    The oral exam will focus mainly on the topics covered during the lectures and will have the purpose to evaluate not only if the student has acquired the learning outcomes but also  if he/she has acquired adequate terminology and the ability to analyze with a critical sense and synthesis the proposed arguments.

    Exam schedule

    Date Time Location Type Notes
    17/01/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.
    14/02/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.
    14/06/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.
    05/07/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.
    26/07/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.
    09/09/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.
    26/09/2022 09:30 GENOVA Orale L'esame si svolgerà in presenza nell'auletta piano terra di Patologia Generale via L.B. Alberti 2, a partire dalle 9.30.