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PROTEIN ENGINEERING

CODICE 95322
ANNO ACCADEMICO 2020/2021
CFU 5 cfu al 2° anno di 10598 MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY (LM-9) GENOVA
SETTORE SCIENTIFICO DISCIPLINARE BIO/10
LINGUA Inglese
SEDE GENOVA (MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY)
PERIODO 2° Semestre
MATERIALE DIDATTICO AULAWEB

PRESENTAZIONE

OBIETTIVI E CONTENUTI

OBIETTIVI FORMATIVI

The aim of the course is to provide students with theoretical knowledge but also practical on the assumptions and techniques underlying the engineering of proteins and antibodies. In addition, part of the course will be dedicated to the deepening of the techniques of chemical synthesis of proteins. Regarding the form of Protein engineering, will initially be resumed and expanded some concettivi base relative to the production of recombinant proteins. Thus, different approaches will be analyzed in order to obtain modified proteins or optimized for different applications, the techniques used and the systems of selection / screening, and using examples from the literature or used for production / commercial. In the section of the course on the engineering of antibodies will be given with the three-dimensional structure of immunoglobulins and will be addressed later, in the chronological order of creation, the different techniques of humanization and production of recombinant phage display antibody. In the form of Chemical Engineering explain the main techniques for the chemical synthesis of peptides and proteins and applications resulting from these techniques.

DOCENTI E COMMISSIONI

Commissione d'esame

MICHELA TONETTI (Presidente)

FABIO GIUSEPPE GHIOTTO

ENRICO MILLO