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BIOINFORMATICS

CODICE 106746
ANNO ACCADEMICO 2021/2022
CFU
  • 6 cfu al 1° anno di 11159 BIOENGINEERING(LM-21) - GENOVA
  • SETTORE SCIENTIFICO DISCIPLINARE ING-INF/06
    SEDE
  • GENOVA
  • PERIODO 2° Semestre
    MATERIALE DIDATTICO AULAWEB

    OBIETTIVI E CONTENUTI

    OBIETTIVI FORMATIVI

    Bioinformatics is the study of how information is represented and analyzed in biological systems, especially information derived at the molecular level. The course will focus on the methodological and technological basis of bioinformatics, they include the creation and management of standard terminologies and data representations, the integration of heterogeneous databases, the organization and searching of the biomedical literature, the use of machine learning techniques to extract new knowledge, the simulation of biological processes, and the creation of knowledge-based systems to support advanced practitioners in the field.

    OBIETTIVI FORMATIVI (DETTAGLIO) E RISULTATI DI APPRENDIMENTO

    Students will be provided with the basic informatic and biochemical knowledge (including molecular biology, genetics, organic chemistry, statistics and programming) essential to face complex data management problems such as predictions, gene regulation, protein-protein communication networks, as well as to use the available databases effectively / efficiently.

    PREREQUISITI

    • Basic knowledge of Chemistry: structure of matter, inter / intramolecular bonds, energy potentials
    • Basic knowledge of biology: meaning of Mendelian genetics, the concept of evolution, nucleic acids, proteins.
    • Data management and analysis
    • Knowledge of logic programming

    MODALITA' DIDATTICHE

    48 hours of classroom lessons, unless otherwise indicated by the Ministerial guidelines

    PROGRAMMA/CONTENUTO

    Biological basis for Bioinformatics

    Basic notions of organic chemistry and molecular biology

    Notions of Genetics.

    gene sequences and evolution: point mutations, gene duplication, chromosomal rearrangement

    Databases of biological interest

    Web platforms: EnsEMBL, GenBank, Genome Browser

    Sequence Alignment (Alignment of Sequence Pairs, Alignment Algorithms, Scoring of an alignment)

    Homology, identity, and similarity of genes

    Similarity matrices of scoring and substitution, BLAST

    Clustal. Algorithm.

    Gene regulation and differential analysis

    The 20 amino acids: chemical-physical characteristics, one and three letters code.

    Elements of Protein Structure and prediction.

    Databases of protein structures: Uniprot, Protein Data Bank, Expasy proteomics tools.

    Molecular dynamics and docking simulation software

    Use of R language and Bioconductor libraries

    TESTI/BIBLIOGRAFIA

    DOCENTI E COMMISSIONI

    Commissione d'esame

    CAMILLO ROSANO (Presidente)

    VITTORIO SANGUINETI

    LEZIONI

    Orari delle lezioni

    L'orario di tutti gli insegnamenti è consultabile su EasyAcademy.

    ESAMI

    MODALITA' D'ESAME

    • Didactic methods
      • 48 hours of classroom lessons, unless otherwise indicated by the Ministerial guidelines
         
    • Method of examination
      • Presentation of a project work, and oral exam

    MODALITA' DI ACCERTAMENTO

    • Assessment method

    The practical test aims to verify students’ acquired knowledge of basic bioinformatics notions, and their ability to face up a bio-chemical problems by consulting databases and using open source informatic tools available in scientific bibliography.

    The oral exam will mainly focus on the topics covered during the lectures and must confirm that the student has acquired the basic notions (biological, chemical and IT) provided by the course.

    Calendario appelli

    Data Ora Luogo Tipologia Note
    06/06/2022 09:00 GENOVA Scritto + Orale
    22/06/2022 09:00 GENOVA Scritto + Orale
    11/07/2022 09:00 GENOVA Scritto + Orale
    27/07/2022 09:00 GENOVA Scritto + Orale
    14/09/2022 09:00 GENOVA Scritto + Orale