|SETTORE SCIENTIFICO DISCIPLINARE||ING-INF/06|
|LINGUA||Italiano (Inglese a richiesta)|
Bioinformatics is the study of how information is represented and analyzed in biological systems, especially information derived at the molecular level. The course will focus on the methodological and technological basis of bioinformatics, they include the creation and management of standard terminologies and data representations, the integration of heterogeneous databases, the organization and searching of the biomedical literature, the use of machine learning techniques to extract new knowledge, the simulation of biological processes, and the creation of knowledge-based systems to support advanced practitioners in the field.
Students will be provided with the basic informatic and biochemical knowledge (including molecular biology, genetics, organic chemistry, statistics and programming) essential to face complex data management problems such as predictions, gene regulation, protein-protein communication networks, as well as to use the available databases effectively / efficiently.
48 hours of classroom lessons, unless otherwise indicated by the Ministerial guidelines
Biological basis for Bioinformatics
Basic notions of organic chemistry and molecular biology
Notions of Genetics.
gene sequences and evolution: point mutations, gene duplication, chromosomal rearrangement
Databases of biological interest
Web platforms: EnsEMBL, GenBank, Genome Browser
Sequence Alignment (Alignment of Sequence Pairs, Alignment Algorithms, Scoring of an alignment)
Homology, identity, and similarity of genes
Similarity matrices of scoring and substitution, BLAST
Gene regulation and differential analysis
The 20 amino acids: chemical-physical characteristics, one and three letters code.
Elements of Protein Structure and prediction.
Databases of protein structures: Uniprot, Protein Data Bank, Expasy proteomics tools.
Molecular dynamics and docking simulation software
Use of R language and Bioconductor libraries
L'orario di tutti gli insegnamenti è consultabile su EasyAcademy.
The practical test aims to verify students’ acquired knowledge of basic bioinformatics notions, and their ability to face up a bio-chemical problems by consulting databases and using open source informatic tools available in scientific bibliography.
The oral exam will mainly focus on the topics covered during the lectures and must confirm that the student has acquired the basic notions (biological, chemical and IT) provided by the course.