CODICE 106746 ANNO ACCADEMICO 2023/2024 CFU 6 cfu anno 1 BIOENGINEERING 11159 (LM-21) - GENOVA SETTORE SCIENTIFICO DISCIPLINARE ING-INF/06 LINGUA Inglese SEDE GENOVA PERIODO 2° Semestre MATERIALE DIDATTICO AULAWEB OBIETTIVI E CONTENUTI OBIETTIVI FORMATIVI Alla fine del corso gli studenti dovranno essere capaci di utilizzare strumenti opensource per la gestione dei dati biologici, capire e consultare banche dati (genebank, NCBI, Uniprot, ecc) accedendovi anche da appositi pacchetti R. Sarà inoltre capace di capire i processi biologici alla base della trascrizione e la traduzione cellulare, per capire l'utilità dell'analisi dei dati genomici, trascrittomici e proteomici attraverso strumenti bioinformatici. OBIETTIVI FORMATIVI (DETTAGLIO) E RISULTATI DI APPRENDIMENTO Students will be provided with the basic informatic and biochemical knowledge (including molecular biology, genetics, organic chemistry, statistics and programming) essential to face complex data management problems such as predictions, gene regulation, protein-protein communication networks, as well as to use the available databases effectively / efficiently. PREREQUISITI Basic knowledge of Chemistry: structure of matter, inter / intramolecular bonds, energy potentials Basic knowledge of biology: meaning of Mendelian genetics, the concept of evolution, nucleic acids, proteins. Data management and analysis Knowledge of logic programming MODALITA' DIDATTICHE 48 hours of classroom lessons, unless otherwise indicated by the Ministerial guidelines PROGRAMMA/CONTENUTO Biological basis for Bioinformatics Basic notions of organic chemistry and molecular biology Notions of Genetics. gene sequences and evolution: point mutations, gene duplication, chromosomal rearrangement Databases of biological interest Web platforms: EnsEMBL, GenBank, Genome Browser Sequence Alignment (Alignment of Sequence Pairs, Alignment Algorithms, Scoring of an alignment) Homology, identity, and similarity of genes Similarity matrices of scoring and substitution, BLAST Clustal. Algorithm. Gene regulation and differential analysis The 20 amino acids: chemical-physical characteristics, one and three letters code. Elements of Protein Structure and prediction. Databases of protein structures: Uniprot, Protein Data Bank, Expasy proteomics tools. Molecular dynamics and docking simulation software Use of R language and Bioconductor libraries TESTI/BIBLIOGRAFIA Bibliography Paul M. Selzer, Richard J. Marhöfer, Oliver Koch. Applied Bioinformatics. Springer International Publishing AG. Available online at the link: https://link.springer.com/book/10.1007/978-3-319-68301-0 Slides provided by teachers DOCENTI E COMMISSIONI GABRIELA FERNANDA CORONEL VARGAS CAMILLO ROSANO Commissione d'esame CAMILLO ROSANO (Presidente) GABRIELA FERNANDA CORONEL VARGAS VITTORIO SANGUINETI (Presidente Supplente) LEZIONI INIZIO LEZIONI https://corsi.unige.it/11159/p/studenti-orario Orari delle lezioni L'orario di questo insegnamento è consultabile all'indirizzo: Portale EasyAcademy ESAMI MODALITA' D'ESAME Didactic methods 48 hours of classroom lessons, unless otherwise indicated by the Ministerial guidelines Method of examination Presentation of a project work, and oral exam MODALITA' DI ACCERTAMENTO Assessment method The practical test aims to verify students’ acquired knowledge of basic bioinformatics notions, and their ability to face up a bio-chemical problems by consulting databases and using open source informatic tools available in scientific bibliography. The oral exam will mainly focus on the topics covered during the lectures and must confirm that the student has acquired the basic notions (biological, chemical and IT) provided by the course. Calendario appelli Data appello Orario Luogo Tipologia Note 03/06/2024 10:00 GENOVA Scritto + Orale 21/06/2024 10:00 GENOVA Scritto + Orale 15/07/2024 10:00 GENOVA Scritto + Orale 29/07/2024 09:00 GENOVA Scritto + Orale 29/07/2024 10:00 GENOVA Scritto + Orale 09/09/2024 10:00 GENOVA Scritto + Orale 11/09/2024 09:00 GENOVA Scritto + Orale OpenBadge PRO3 - Soft skills - Creazione progettuale avanzato 1 - A