PRESENTAZIONE

The course is giving basic information about solid-phase synthesis and its applications

OBIETTIVI E CONTENUTI

OBIETTIVI FORMATIVI

The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.

MODALITA' DIDATTICHE

Lectures, bibliographic search through serching engines, powerpoint presentations

PROGRAMMA/CONTENUTO

Soluble and insoluble polymers. Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports. Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods. Combinatorial chemistry: use and applications. Parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests. Combinatorial chemistry and material science. Literature search

TESTI/BIBLIOGRAFIA

“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3

“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6 

DOCENTI E COMMISSIONI

Commissione d'esame

ANDREA BASSO (Presidente)

PAOLA RIANI

LEZIONI

Orari delle lezioni

L'orario di questo insegnamento è consultabile all'indirizzo: Portale EasyAcademy

ESAMI

MODALITA' D'ESAME

Oral examination and powerpoint presentation

MODALITA' DI ACCERTAMENTO

The students will be asked to prepare a powerpoint presentation on a specific subject, chosen in agreement with the teacher. The main exam will be an oral examination where general questions on the course matter will be asked

Calendario appelli