CODICE | 94833 |
---|---|
ANNO ACCADEMICO | 2018/2019 |
CFU | 3 cfu al 1° anno di 9017 SCIENZA E INGEGNERIA DEI MATERIALI (LM-53) GENOVA |
SETTORE SCIENTIFICO DISCIPLINARE | CHIM/06 |
LINGUA | Inglese |
SEDE | GENOVA (SCIENZA E INGEGNERIA DEI MATERIALI ) |
PERIODO | 2° Semestre |
MATERIALE DIDATTICO | AULAWEB |
The course is giving basic information about solid-phase synthesis and its applications
The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.
Traditional lectures, Computer-room laboratory for bibliographic search through serching engines, elaboration of powerpoint presentations and relevant discussion
Introduction to the drug discovery process and to the limitations connected with traditional synthesis.
Use of enabling technologies to speed the purification processes: soluble and insoluble polymers.
Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports.
Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods.
Combinatorial chemistry: parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests.
Combinatorial chemistry and material science: introduction, general principles, analogy and differences with organic synthesis combichem
Examples taken from the recent literature
The use of search engines
“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3
“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6
Ricevimento: on appointment
ANDREA BASSO (Presidente)
PAOLA RIANI
Traditional lectures, Computer-room laboratory for bibliographic search through serching engines, elaboration of powerpoint presentations and relevant discussion
L'orario di tutti gli insegnamenti è consultabile su EasyAcademy.
Oral examination and powerpoint presentation
The students will be asked to prepare a powerpoint presentation on a specific subject, chosen in agreement with the teacher. The main exam will be an oral examination where general questions on the course matter will be asked
Data | Ora | Luogo | Tipologia | Note |
---|---|---|---|---|
13/06/2019 | 15:00 | GENOVA | Orale | |
27/06/2019 | 15:00 | GENOVA | Orale | |
25/07/2019 | 15:00 | GENOVA | Orale | |
19/09/2019 | 15:00 | GENOVA | Orale |