OBIETTIVI FORMATIVI

The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.

MODALITA' DIDATTICHE

Traditional lectures, Computer-room laboratory for bibliographic search through serching engines, elaboration of powerpoint presentations and relevant discussion

PROGRAMMA/CONTENUTO

Introduction to the drug discovery process and to the limitations connected with traditional synthesis.

Use of enabling technologies to speed the purification processes: soluble and insoluble polymers.

Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports.

Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods.

Combinatorial chemistry: parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests.

Combinatorial chemistry and material science: introduction, general principles, analogy and differences with organic synthesis combichem

Examples taken from the recent literature

The use of search engines

TESTI/BIBLIOGRAFIA

“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3

“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6