CODICE 94833 ANNO ACCADEMICO 2019/2020 CFU 3 cfu anno 1 SCIENZA E INGEGNERIA DEI MATERIALI 9017 (LM-53) - GENOVA 3 cfu anno 2 SCIENZA E INGEGNERIA DEI MATERIALI 9017 (LM-53) - GENOVA SETTORE SCIENTIFICO DISCIPLINARE CHIM/06 LINGUA Inglese SEDE GENOVA PERIODO 2° Semestre MATERIALE DIDATTICO AULAWEB PRESENTAZIONE The course is giving basic information about solid-phase synthesis and its applications OBIETTIVI E CONTENUTI OBIETTIVI FORMATIVI The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science. MODALITA' DIDATTICHE Traditional lectures, Computer-room laboratory for bibliographic search through serching engines, elaboration of powerpoint presentations and relevant discussion PROGRAMMA/CONTENUTO Introduction to the drug discovery process and to the limitations connected with traditional synthesis. Use of enabling technologies to speed the purification processes: soluble and insoluble polymers. Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports. Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods. Combinatorial chemistry: parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests. Combinatorial chemistry and material science: introduction, general principles, analogy and differences with organic synthesis combichem Examples taken from the recent literature The use of search engines TESTI/BIBLIOGRAFIA “Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3 “Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6 DOCENTI E COMMISSIONI ANDREA BASSO Ricevimento: su appuntamento LEZIONI Orari delle lezioni L'orario di questo insegnamento è consultabile all'indirizzo: Portale EasyAcademy ESAMI MODALITA' D'ESAME Oral examination and powerpoint presentation MODALITA' DI ACCERTAMENTO The students will be asked to prepare a powerpoint presentation on a specific subject, chosen in agreement with the teacher. The main exam will be an oral examination where general questions on the course matter will be asked Calendario appelli Data appello Orario Luogo Tipologia Note 10/06/2020 15:00 GENOVA Orale 26/06/2020 15:00 GENOVA Orale 23/07/2020 15:00 GENOVA Orale 17/09/2020 15:00 GENOVA Orale
