CODE 66712 ACADEMIC YEAR 2016/2017 CREDITS 3 cfu anno 2 MONITORAGGIO BIOLOGICO 9016 (LM-6) - SCIENTIFIC DISCIPLINARY SECTOR BIO/14 LANGUAGE Italiano TEACHING LOCATION SEMESTER 2° Semester AIMS AND CONTENT LEARNING OUTCOMES The course provides update knowledge on toxicokinetic and toxicodynamic of an exogenous compound within an organism; mechanisms of toxicity: functional toxicity, cytotoxicity, genotoxicity, teratology and feotal toxicity; side and toxic effects of drugs, toxicity of xenobiotics; toxicity at level of tissues and organs. LEARNING OUTCOMES (FURTHER INFO) The course provides update knowledge on toxicokinetic and toxicodynamic of an exogenous compound within an organism; mechanisms of toxicity: functional toxicity, cytotoxicity, genotoxicity, teratology and feotal toxicity; side and toxic effects of drugs, toxicity of xenobiotics; toxicity at level of tissues and organs. TEACHING METHODS Frontal lessons SYLLABUS/CONTENT 1 Essential lexicon in Pharmacology and Toxicology: active substances (drugs; medicinal preparations; medicinal herbes; placebo), xenobiotics. Scope of the field. 2 Acute and chronic toxicological studies. Therapeutic Index and Certain Safety Factor 3 exposure and risk assessment 4 Toxicokinetic 5 Molecular aspects of Toxicity: structure-activity relationship; cytotoxicity; carcinogenesis; teratology 6 Toxicological pathology of the central nervous system: Neuronopathy, Axonopathy, Synaptopathy, Myelinopathy. 7 Neurotoxicity and the neurotransmission: excitotoxicity. Toxins and vesicular release 8 Heavy Metals Toxicity 9 Nephrotoxicology RECOMMENDED READING/BIBLIOGRAPHY Casarett & Doull. Elementi di Tossicologia Edizione italiana a cura di Patrizia Hrelia e Giorgio Cantelli Forti Casa Editrice Ambrosiana Notes of Lesson TEACHERS AND EXAM BOARD CHIARA CERVETTO Ricevimento: Appointment Exam Board CHIARA CERVETTO (President) MANUELA MARCOLI GUIDO MAURA ANNA MARIA PITTALUGA LESSONS LESSONS START II semestre Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral examination ASSESSMENT METHODS To assess student’s achievement of learning, the examination will be an oral exam (30 minutes), always in presence of the Commission consisting of at least of two professors (or sometime in presence of a professor and an expert subject designated by the CCS). The Commission will verify the achievement of educational objectives with high accuracy collecting informations about the nature and extent of learning outcomes, capacity as well as connection and reasoning within topics of the Course. When the educational objectives will be not achieved, the Student will be invited to verify better the knowledge and possibly to use supplemental explanations contacting the professor. Exam schedule Data appello Orario Luogo Degree type Note 15/06/2017 09:30 GENOVA Orale 27/06/2017 09:30 GENOVA Orale 20/07/2017 09:30 GENOVA Orale 11/09/2017 09:30 GENOVA Orale 26/09/2017 09:30 GENOVA Orale