The course aims at providing students with basic knowledge of the molecular mechanisms supporting the principal cell functions.
The main aim of the course is to provide an overview of the cell as a functional autonomous unit as well as a component of more complex structures.
Aim of this course is to provide students with the knowledge of the mechanisms regulating transmission and expression of genetic information; the cellular and molecular mechanisms regulating the proliferation and the differentiation of eukaryotic cells; the cellular and molecular mechanisms underlying the interaction of the eukaryotic cell with other cells; the genetic basis of development and evolution.
The course includes classroom teaching on topics of Cell and Molecular Biology and Genetics.
The course is divided in 4 main areas:
1. Macromolecules and general biology – Topics to be developed: Basic structure and properties of nucleic acids, proteins, lipids and carbohydrates shall be presented with focus on chemical bonds and molecular structure and interactions to provide notions to understand the basic cell biology. Principles of classification of living organisms. Species and speciation. Cell theory: prokaryotes eukaryotes, general organization and their genomes, molecular evolution. phylogenetic trees.
2. Gene expression - Topics to be developed: Nucleic acids structure and functions, DNA duplication, transcription, translation, gene expression regulation.
3. Cell proliferation - Topics to be developed: Cell cycle and control mechanisms, mitosis, meiosis, gametogenesis, mechanisms and meaning of cell death (apoptosis and necrosis), mechanisms of cell differentiation and cell transformation.
4. Basic genetics - Topics to be developed: Genetic significance of meiosis and gametogenesis. Basic notions of classical genetics.
Alberts et al.; "L'essenziale di biologia molecolare della cellula"; Zanichelli Editori.
-Becker et al.; "Il mondo della cellula"; Pearsons Eds.
-Solomon et al.; "Biologia"; Edises
-Karp et al.; "Biologia cellulare e molecolare"; Edises
-Pollard et a.; "Biologia Cellulare"; Elsevier-Masson Eds.
-Russell et al.; “Genetica, un approccio moelcolare”, Pearson
Ricevimento: By appointment by email: rodolfo.quarto@unige.it
PAOLA GHIORZO (President)
EMANUELA MARCENARO (President)
ROBERTA CASTRICONI
ALESSANDRO MORETTA
ANTONIO PUCCETTI
SONIA SCARFI'
SIMONA SIVORI
RODOLFO QUARTO (President and Coordinator of Integrated Course)
Final test is based on a multiple choice test.
Passing of the written test is achieved with at least a score of 18/30, and at least 6/10 for each single module.
