CODE 61198 ACADEMIC YEAR 2016/2017 CREDITS 3 cfu anno 2 MEDICINA E CHIRURGIA (LM-41) - SCIENTIFIC DISCIPLINARY SECTOR MED/07 LANGUAGE Italiano TEACHING LOCATION SEMESTER 2° Semester MODULES Questo insegnamento è un modulo di: ETIOLOGY AND PATHOGENESIS OF DISEASES OVERVIEW Microbiology is a science that studies microorganisms, microscopic organisms having an extraordinary impact on the entire life and the composition of our planet. Microorganisms and humans have a very close relationship.Some thousands of microbial species, collectively known as microbiota, live in our body and plays useful functions, instead other species, pathogens, may cause morbidity.The students should know the biology of the microorganisms and their strategies to cause diseases in humans. AIMS AND CONTENT LEARNING OUTCOMES (FURTHER INFO) General Microbiology: To know the main characteristics of prokaryotes, eukaryotes and viruses and their classification. The host-microbe interactions (symbiosis, parasitism, opportunism, colonization, infection, disease). General Bacteriology: To know the characteristics of bacteria (bacterial structure, growth and microbial metabolism, overview of bacterial genetics). To understand the bacterial pathogenicity and virulence factors (input, adherence to host tissue, invasion, permanence, exotoxins and endotoxins, hydrolytic enzymes, antiphagocytic mechanisms), intracellular parasites and heterogeneity antigen. To know the major classes of chemotherapeutic agents and antibiotics (beta-lactams, glycopeptides, aminoglycosides, tetracyclines, quinolones, chloramphenicol, macrolides, clindamycin, oxazolidinones, streptogramins, nitroimidazoles, rifampin) and their main characteristics (spectrum of action, target, pharmacokinetics and mechanisms of drug resistance). Susceptibility and antimicrobial resistance and quantitative and qualitative determination of antibiotic activity. General Virology: To know the general characteristics of the viruses (structure and composition, viral classification, viral replication, viral genetics overview). To understand the mechanism of viral penetration into the host, viral transmission, spreading, tropism, virulence and cytopathic effects, persistence, latency, reactivation). To know the antiviral drugs and resistances. Mycology and parasitology: To know the general characteristics of pathogenic fungi and parasites. TEACHING METHODS The teaching methods include: lectures (30 total hours) SYLLABUS/CONTENT -Main characteristics of prokaryotes, eukaryotes and viruses and their classification. -The host-microbe interactions (symbiosis, parasitism, opportunism, colonization, infection, disease). - Characteristics of bacteria (bacterial structure, growth and bacterial metabolism, overview of bacterial genetics) . -Bacterial pathogenicity and virulence factors (input, adherence to host tissue, invasion, permanence, exotoxins and endotoxins, hydrolytic enzymes, antifagocitari mechanisms). -Intracellular parasites and heterogeneity antigen. -Classification of antibiotics (beta-lactams, glycopeptides, aminoglycosides, tetracyclines, quinolones, chloramphenicol, macrolides, clindamycin, oxazolidinones, streptogramins, nitroimidazoles, rifampin). -Antibiotics: spectrum of activity, target, pharmacokinetics and mechanisms of drug resistance. Susceptibility and antimicrobial resistance and quantitative and qualitative determination of antibiotic activity. - General characteristics of viruses (structure and composition, viral classification, viral replication, viral genetics overview). -Mechanism of viral penetration into the host, viral transmission, spreading, tropism, virulence and cytopathic effects, persistence, latency, reactivation). Antiviral drugs and resistances. - General characteristics of pathogenic fungi and parasites. RECOMMENDED READING/BIBLIOGRAPHY AA.VV. Principi di microbiologia Medica. Casa Editrice Ambrosiana TEACHERS AND EXAM BOARD EUGENIO DEBBIA Ricevimento: By appointment by email: eugenio.debbia@unige.it ANNA MARCHESE ANNA MARIA SCHITO Exam Board CLAUDIA CANTONI (President) GABRIELLA PIETRA (President) GIOVANNA BIANCHI EUGENIO DEBBIA ANNA MARCHESE GABRIELLA PIATTI MARIA ADELAIDE PRONZATO OLIVIERO VARNIER MARIA CRISTINA MINGARI (President and Coordinator of Integrated Course) LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral examination ASSESSMENT METHODS The evaluation is carried out through the only final exam which seeks to ascertain the actual acquisition by the student of the expected learning results. To demonstrate their knowledge, the students will be able to know: -the main characteristics of prokaryotes, eukaryotes and viruses and their classification. The host-microbe interactions (symbiosis, parasitism, opportunism, colonization, infection, disease); -the characteristics of bacteria (bacterial structure, growth and microbial metabolism, overview of bacterial genetics); -the bacterial pathogenicity and virulence factors (input, adherence to host tissue, invasion, permanence, exotoxins and endotoxins, hydrolytic enzymes, antiphagocytic mechanisms), intracellular parasites and heterogeneity antigen; -the major classes of chemotherapeutic agents and antibiotics (beta-lactams, glycopeptides, aminoglycosides, tetracyclines, quinolones, chloramphenicol, macrolides, clindamycin, oxazolidinones, streptogramins, nitroimidazoles, rifampin) and their main characteristics (spectrum of action, target, pharmacokinetics and mechanisms of drug resistance); -susceptibility and antimicrobial resistance and quantitative and qualitative determination of antibiotic activity; -the general characteristics of the viruses (structure and composition, viral classification, viral replication, viral genetics overview); -the mechanism of viral penetration into the host, viral transmission, spreading, tropism, virulence and cytopathic effects, persistence, latency, reactivation); -the antiviral drugs and resistances; -the general characteristics of pathogenic fungi and parasites. A minimum mark of 18/30 is required to pass the module. The mark 30/30 with any honors will correspond to an excellent knowledge of all argoments. Exam schedule Data appello Orario Luogo Degree type Note 13/04/2017 14:00 GENOVA Scritto 19/04/2017 14:00 GENOVA Orale 20/04/2017 14:00 GENOVA Orale 12/06/2017 10:00 GENOVA Scritto 19/06/2017 09:00 GENOVA Orale 20/06/2017 14:00 GENOVA Scritto 28/06/2017 10:00 GENOVA Scritto 03/07/2017 09:00 GENOVA Orale 11/07/2017 10:00 GENOVA Scritto 19/07/2017 09:00 GENOVA Orale 25/07/2017 14:00 GENOVA Scritto 11/09/2017 10:00 GENOVA Scritto 14/09/2017 09:00 GENOVA Orale 25/09/2017 10:00 GENOVA Scritto 26/09/2017 14:00 GENOVA Scritto 20/12/2017 09:00 GENOVA Orale