Pharmacology is the science that study the interactions between the drugs and the body. This include the study of the origin and the chemical structure of the drugs, the molecular mechanisms the mediate their effects inthe the body, the pharmacokinetics, their clinical use, their toxicity, and the adverse reactions that they can determine.
The aim of this course is to provide the students with knowledge about fundamental concepts of the main pharmacological classes required to be able to administer the drugs commonly used during the odontoiatric practice, including their composition therapeutic effects and ADRs. Furthermore the student have to learn the effects, contraindications and adverse reactions of drugs prescribed to the patients that could interfere with his paractice and the knowledge of the drugs used in emergency.
The main learning outcome of the Pharmacology course is acquisition of all the basic information required to be able to prescribe and administered the drugs relevant for the Odontoiatric practice including mechanism of action, therapeutic indications, ADRs, and contraindications.
In detail the student have to get knowledge on:
the molecular and cellular targets that mediate the drug therapeutic and adverse effects;
administration modality and the fate of the drugs within the body, inclding the mechaisms of drug distribution, metabolism amd elimination;
the mechanisms mediating the development of the adverse drug reactions and their toxic effects; the possible causes of hydiosyncratic and allergig reactions toward drugs, included principle of pharmacogenetics and of drug-drug interactions;
the criteria to select different molecules within the same pharmacological class, referring to their potential toxicity and individual features of the patient.
Frontal lessons.
1) Introduction to the pharmacology
Drug development and their preclinical and clinical trials
Pharmacognosy
2) Drug administration routes
Bioavailability
Drug adsorption
Distribution
Drug metabolism and its modulation
Drug excretion
3) Drug activity: agonism antagonism
Therapeutic index
Tolerance
4) Receptor and their functioning as mechanism of action of the drugs
5) Adverse drug reactions and mechanisms inducing the individual differences in the drug activity
6) Drug acting on the autonomic nervous system
7) Local anesthetics
8) NSAID
9) Glucocorticoids
10) Benzodiazepines
11) Basics of antibacterial therapy
12) Beta-lactamic antibiotics (penicillins, cephalosporins, etc)
13) Glycopeptides
14) Macrolides
15) Fluorochinolones and other secnond choice antibiotics
16) Aminoglucosides, tetracyclines, CAF
17) Antifungines
18) Antiviral drugs
19) Antiplatelets, anticoagulats, antihaemerragic drugs
20) drugs affecting calcium metabolism
21) Antihistaminergic drugs
22) Drugs used in emergency
23) Drug prescription rules
1) Amico-Roxas M., Caputi A., Del Tacca M., Farmacologia in Odontoiatria, UTET
2) Katzung, Farmacologia, Piccin
All the slides used during the lessons will be made available to the students through aulaweb
Ricevimento: Everyday, after appointment (tel 010-3538806, e-mail: tullio.florio@unige.it) at the office at the ex-Institute of Pharmacology in viale Benedetto VX, 2.
TULLIO FLORIO (President)
ALBIANA PINO (President)
II semester
Oral
