OVERVIEW

The course of Toxicology is intended to provide students with an uptade knowledge of the toxicological agents and, in particular, of the interactions that occurs between chemicals and the living organism and that determine toxicological events.

AIMS AND CONTENT

LEARNING OUTCOMES

The course  provides update knowledge on toxicokinetic and toxicodynamic of an exogenous compound within an organism; mechanisms of toxicity: functional toxicity, cytotoxicity, genotoxicity, teratology and feotal toxicity; side and toxic effects of drugs, toxicity of xenobiotics; toxicity at level of tissues and organs.

AIMS AND LEARNING OUTCOMES

The course  provides update knowledge on toxicokinetic and toxicodynamic of an exogenous compound within an organism; mechanisms of toxicity: functional toxicity, cytotoxicity, genotoxicity, teratology and feotal toxicity; side and toxic effects of drugs, toxicity of xenobiotics; toxicity at level of tissues and organs.

TEACHING METHODS

Frontal lessons

SYLLABUS/CONTENT

Essential lexicon in Pharmacology and Toxicology: active substances (drugs; medicinal preparations; medicinal herbes; placebo), xenobiotics, toxicological agent. Scope of the field.

Acute and chronic toxicological studies. Therapeutic Index and Margin of Safety, NOEL, LOEL

 Exposure, Hazard, Risk, risk assessment and management

Toxicokinetic

Molecular aspects of Toxicity: structure-activity relationship; cytotoxicity; carcinogenesis; teratology 

Toxicology of the central nervous system: Neuronopathy, Axonopathy, Synaptopathy, Myelinopathy.

Neurotoxicity and the neurotransmission: excitotoxicity. Toxins and vesicular release

Heavy Metals Toxicity

Toxicity of biotechnological drugs

Marine Biotoxins

RECOMMENDED READING/BIBLIOGRAPHY

Casarett & Doull. Elementi di Tossicologia
Edizione italiana a cura di Patrizia Hrelia e Giorgio Cantelli Forti
Casa Editrice Ambrosiana

Notes of Lesson

TEACHERS AND EXAM BOARD

Exam Board

CHIARA CERVETTO (President)

MANUELA MARCOLI

GUIDO MAURA

ANNA MARIA PITTALUGA

LESSONS

LESSONS START

II semester

Class schedule

The timetable for this course is available here: Portale EasyAcademy

EXAMS

EXAM DESCRIPTION

Oral examination

ASSESSMENT METHODS

To assess student’s achievement of learning, the examination will be an oral exam (30 minutes), always in presence of the Commission consisting of at least of two professors (or sometime in presence of a professor and an expert subject designated by the CCS).  The Commission will verify the achievement of educational objectives with high accuracy collecting informations about the nature and extent of learning outcomes, capacity as well as connection and reasoning within topics of the Course. When the educational objectives will be not achieved, the Student will be invited to verify better the knowledge and possibly to use supplemental explanations contacting the professor.

Exam schedule