The aim of the course is to provide knowledge of the structure, reactivity and properties of complex molecules, with a special focus on biomolecules.
The course will provide an in-depth knowledge of the structure, reactivity and properties of complex molecules. It is developed through three successive steps: (i) classification and structure of functional groups characterizing the main classes of compounds in organic chemistry and bases on the chemistry of coordination compounds, (ii) reactivity and reaction mechanisms for the conversion of such classes of compounds, iii) description of structure, properties and reactivity of polyfunctional macromolecules of biological and biomedical / technological interest
Lectures
Functional groups, IUPAC nomenclature and classifications of main organic compounds. Single bonds: alkanes, alcohols, ethers, amines. Double bonds: alkenes, carbonyl compounds (aldehydes, ketones, carboxylic acids and functional derivatives of carboxylic acids), imines. Triple bonds: alkynes and nitriles. Saturated cyclic compounds: cycloalkanes. Aromatic hydrocarbons: benzene and main derivatives. Organic compounds of nitrogen, sulfur and phosphorus. Properties. Stereochemistry. Main organic reaction mechanisms: nucleophilic substitution, electrophilic addition, elimination, nucleophilic addition, nucleophilic acyl substitution, chemical reactivity of benzene. Synthetic polymers: polymerisation reactions and structure-property relations. Molecules of biological interest: carbohydrates (monosaccharides, disaccharides, polysaccharides), amino acids and proteins, lipids, DNA and RNA. Coordination complexes.
Lecture notes, aulaweb, Chemistry reference textbooks: J.McMurry, Fundamentals of Organic Chemistry; W.Brown, T.Poon, Introduction to Organic Chemistry, J.Wiley and Sons; J.G.Smith, Organic Chemistry, McGraw Hill
Ricevimento: By appointment. E-mail: Elisabetta.Finocchio@unige.it, phone: 010.3536040. Address: DICCA, P.le J.F.Kennedy, 1, Pad. D, 2nd floor (Genova)
SANTINA BRUZZONE (President)
ELISABETTA FINOCCHIO (President)
GIANLUCA DAMONTE
GIANGUIDO RAMIS
CHEMISTRY AND BIOCHEMISTRY - MOD. 1
Oral (partial) exam
After completing this course, the student will be able to manage skills and operating method for the approach of problems related to properties and structure of biomolecules and their reactivity, focusing on their role in technological and biomedical applications
