CODE 95302 ACADEMIC YEAR 2017/2018 CREDITS 6 cfu anno 1 MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY 10598 (LM-9) - SCIENTIFIC DISCIPLINARY SECTOR BIO/13 LANGUAGE English TEACHING LOCATION SEMESTER 1° Semester PREREQUISITES Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY 10598 (coorte 2017/2018) MOLECULAR BIOLOGY 2 AND LABORATORY 95300 TEACHING MATERIALS AULAWEB AIMS AND CONTENT LEARNING OUTCOMES Comprehensive analysis of stem cell biology, with specific focus on their differentiation and therapeutic potential (including somatic nuclear transfer and cloning). TEACHING METHODS Frontal lessons and laboratory. SYLLABUS/CONTENT Stem cells: stemness characterisation and historical background. Embryonic – Fetal – Adult Stem Cells. Stem versus Differentiation Potential. The Stem Cell Niche. Stem Cell Pluripotency and Plasticity. Stem Cell Markers and “Stem Genes”. Adult Stem Cells: Haematopoietic-, Epithelial-, Neural- and Mesenchymal Stem Cells. Somatic Nuclear Transfer in amphibians and mammals. Cloning. Fetal and Perinatal Stem Cells EMT in Cell Biology: Epithelial - Mesenchymal Transition Tissue-Specific Adult Progenitors within the Heart. Epicardial Progenitor Cells (EPDC): Proof-of-Principle of EMT in Cardiac Development and Regeneration. Tissue-Specific Adult Progenitors within the Skeletal Muscle. Stem Cells, DNA damage & Ageing. Stem Cells & miRNA Inter-Cellular Communication 2.0: Extracellular Microvesicles De-Differentiation, Trans-Differentiation and Reprogramming. Journal Club: Oral presentation from groups of students on specific articles from the topic discussed during class. Hands On Practice on Cell Culture Laboratory TEACHERS AND EXAM BOARD SVEVA BOLLINI Ricevimento: By appointment by email: sveva.bollini@unige.it RANIERI CANCEDDA Ricevimento: By appointment by email: ranieri.cancedda@unige.it MADDALENA MASTROGIACOMO Exam Board SVEVA BOLLINI (President) CHIARA GENTILI (President) RANIERI CANCEDDA LESSONS LESSONS START October 1, 2017 Class schedule CELL BIOLOGY II AND LABORATORY COURSE EXAMS EXAM DESCRIPTION Written ASSESSMENT METHODS Written test Exam schedule Data appello Orario Luogo Degree type Note 16/01/2018 14:00 GENOVA Orale 13/02/2018 14:00 GENOVA Orale 18/06/2018 14:00 GENOVA Orale 16/07/2018 14:00 GENOVA Orale 17/09/2018 14:00 GENOVA Orale