CODE 62662 ACADEMIC YEAR 2017/2018 CREDITS 7 cfu anno 2 ODONTOIATRIA E PROTESI DENTARIA 8746 (LM-46) - SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION SEMESTER 2° Semester OVERVIEW Pathology is the study (logos) of suffering (pathos). Is a bridging discipline involving both basic science and clinical practice and is devoted to the study of the structural and functional changes in cells, tissues and organs that underlie disease. Through molecular, microbiological, immunological and morphological studies, General Pathology investigates the different causes of disease and their pathogenic mechanisms to favor the development of effective therapies. AIMS AND CONTENT LEARNING OUTCOMES The learning outcome is the knowledge the main responses of tissues to injuries mediated by exogenous or endogenous agents. TEACHING METHODS Lectures, with any possible dialectic interaction with students SYLLABUS/CONTENT Innate immunity: cells and molecules, local and systemic inflammation, acute and chronic, histological variants of inflammation Adaptive Immunity: generation, education and function of B and T lymphocytes Type I hypersensitivity Mention of immune system’s diseases (immunodeficiencies, autoimmunity and auto-inflammatory diseases) Atherosclerosis and mention of cardiovascular disease and rheumatic fever Oncology: benign and malign neoplasms, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment. Immune responses against cancer, tumor escape mechanisms, tumor-associated inflammation. Environmental causes of disease: causes of physical origin (Radiations, Temperature and different kinds of trauma); causes of chemical origin. Mechanisms of xenobiotic biotransformation. Alimentary causes of disease. Mechanisms of cell damage. Pathological regressive processes: atrophy, degeneration and cell death. Pathological progressive processes: hypertrophy/hyrperplasia, metaplasia and neoplasia. Pathogenesis of fever. RECOMMENDED READING/BIBLIOGRAPHY Robbins & Cotran Pathologic Basis of Disease, Elsevier Abbas & Lichtman Cellular and Molecular Immunology, Elsevier The didactic material is available in pdf format for download (https://www.aulaweb.unige.it). TEACHERS AND EXAM BOARD CRISTINA BOTTINO Ricevimento: By appointment Email: Cristina.Bottino@unige.it MARIA ADELAIDE PRONZATO Ricevimento: Students can contact the teachers by mail Exam Board CRISTINA BOTTINO (President) MARIA ADELAIDE PRONZATO (President) LESSONS LESSONS START 2nd semester, 2nd year Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The students are evaluated in an oral examination. Two professors examine each student about any of the subject of the course program. ASSESSMENT METHODS The oral examination consists in several questions, starting from more general questions to more precise ones, in order to assess the knowledge of the students. Students must know the requested pathogenetic mechanisms and demonstrate the ability to connect different subjects of the program. Exam schedule Data appello Orario Luogo Degree type Note 15/01/2018 09:00 GENOVA Orale 29/01/2018 09:00 GENOVA Orale 12/02/2018 09:00 GENOVA Orale 04/06/2018 09:00 GENOVA Orale 18/06/2018 09:00 GENOVA Orale 09/07/2018 09:00 GENOVA Orale 10/09/2018 09:00 GENOVA Orale 24/09/2018 09:00 GENOVA Orale FURTHER INFORMATION The didactic material is available in pdf format for download (https://www.aulaweb.unige.it) Students can contact the teachers by mail (information, appointment)
