CODE 64767 ACADEMIC YEAR 2017/2018 CREDITS 4 cfu anno 1 CHIMICA INDUSTRIALE 9020 (LM-71) - 4 cfu anno 2 CHIMICA INDUSTRIALE 9020 (LM-71) - SCIENTIFIC DISCIPLINARY SECTOR CHIM/04 LANGUAGE Italian TEACHING LOCATION SEMESTER 1° Semester OVERVIEW In this course the basic concepts aimed to correlate the molecular, chemical-physical and mechanic properties of biomaterials with their functions in biological systems are provided. The different classes of biomaterials, especially the polymeric ones, their application use and the main technological approaches applied in biomedical field are described. AIMS AND CONTENT LEARNING OUTCOMES Knowledge of the main chemical, physical, mechanical properties of biomaterials, especially those of polymeric nature. Acquisition of basic notions about biofunctionality, biocompatibility and hemocompatibility and on issues related to the interactions of biomaterials with biological systems. Examples of specific applications and development strategies of biomaterials. AIMS AND LEARNING OUTCOMES The course aims to provide the basic principles underlying biomedical engineering and the production of controlled release devices as well as to develop the student's ability to apply the theoretical knowledge to formulate general criteria for the design, synthesis, functionalization and characterization of innovative materials and systems. TEACHING METHODS Traditional lectures sometimes accompanied with exercises carried out by the teacher in the classroom. Lesson notes are uploaded to the corresponding AulaWeb page after their content has been developed in the classroom. In order to facilitate the individual preparation of the students, verification tests are uploaded to the corresponding AulaWeb page. SYLLABUS/CONTENT Classification of biomaterials. Polymeric and composite biomaterials. Biodegradable, bioresorbable and bioactive materials. Interaction of biomaterials outside of the blood flow: biostability and biocompatibility. Interaction of biomaterials within the blood flow: hemocompatibility and thrombogenicity. Analysis of biomaterial surfaces: characterization techniques and treatment and functionalization protocols. Polymeric biomaterials for orthopedic, dental, and ophthalmological devices. Polymeric biomaterials for soft tissues. Polymeric biomaterials for cardiovascular devices. Regenerative medical science: tissue engineering and biomimetic materials. Mono-, bi-, and tridimensional scaffolds for tissue architecture: materials and fabrication techniques. Controlled drug delivery systems (DDS). Regulations in force related to biocompatibility matter and main evaluation tests. RECOMMENDED READING/BIBLIOGRAPHY R. Pietrabissa, “Biomateriali per Protesi e Organi Artificiali”, Patron Ed. Bologna, 1996 R. Fumero, P. Giusti, “Biomateriali: dalla ricerca di base all’applicazione clinica”, Patron Ed., Bologna, 1985 C. Di Bello, “Biomateriali-Introduzione allo Studio”, Patron Ed., Bologna, 2005 A. Atala, “Principles of regenerative medicine”, 2nd edition, London: Academic, 2010 “Perspectives on biomaterials: proceedings on the 1985 International Symposium on Biomaterials”, O.C.C- Lin & E.Y.S. Chao, Eds., 1985 J.B. Park, R.S. Lakes, “Biomaterials-An Introduction”, Springer-Verlag, N.Y. Inc., 2007 A.F. von Recum, “Handbook of Biomaterials Evaluation: Scientific, Technical and Clinical Testing of Implant Materials”, CRC Press, 1999 (ISBN 1560324791) TEACHERS AND EXAM BOARD MARINA ALLOISIO Ricevimento: Every day by appointment. Exam Board MARINA ALLOISIO (President) ALDO BOTTINO (President) MAILA CASTELLANO CAMILLA COSTA MASSIMO OTTONELLI LESSONS LESSONS START Available on the official website of Industrial Chemistry degree as soon as the calendar is defined. Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral examination conducted by two teachers for a duration of at least 30 minutes. The oral examination usually consists of two parts; both of them are awarded a maximum rating of 15/30 for the exam evaluation: - in the first part the student has to face a problem with the use of polymeric materials in the biomedical field in order to verify his comprehension and mastery of the course topics as well as his ability to apply theoretical concepts to real situations. Alternatively, and only for the student's specific choice, the first part of the exam can cover a topic, chosen by the student, which is related to the course but not included in the program; in this case, the exam is subordinated to the delivery of a report on the subject, according to the terms set by the teacher. - in the second part, the student is called upon to answer two questions related to topics of the course program, chosen by the exam committee. ASSESSMENT METHODS Goal of the assessment is to verify the student's ability to correlate the potentialities of the various biomaterials with their chemical, physical and mechanical properties. If the learning outcomes are not achieved, the student is invited to deepen his preparation also by taking advantage of further explanations by the teacher. As a quality assurance, the detailed program of the course is uploaded to the corresponding AulaWeb page, so that students can verify the correspondence between topics and learning outcomes. Exam schedule Data appello Orario Luogo Degree type Note 06/02/2018 09:30 GENOVA Orale 20/02/2018 09:30 GENOVA Orale 19/06/2018 09:30 GENOVA Orale 03/07/2018 09:30 GENOVA Orale 17/07/2018 09:30 GENOVA Orale 04/09/2018 09:30 GENOVA Orale 18/09/2018 09:30 GENOVA Orale FURTHER INFORMATION No official pre-requisites. However, it may be useful to have followed a basic course on polymer and on biochemistry.
