CODE 62662 ACADEMIC YEAR 2018/2019 CREDITS 7 cfu anno 2 ODONTOIATRIA E PROTESI DENTARIA 8746 (LM-46) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester TEACHING MATERIALS AULAWEB OVERVIEW Pathology is the study (logos) of suffering (pathos). It is a bridging discipline connecting basic science and clinical practice, and is devoted to the study of the structural and functional changes in cells, tissues and organs that underlie disease. Through molecular, microbiological, immunological and morphological studies, General Pathology investigates the different causes of disease and their pathogenic mechanisms to favor the development of effective therapies. AIMS AND CONTENT LEARNING OUTCOMES The learning outcome is the knowledge the main responses of tissues to injuries mediated by exogenous or endogenous agents. TEACHING METHODS Lectures, with any possible dialectic interaction with students SYLLABUS/CONTENT Environmental factors of disease: physical causes (radiation, temperature extremes and mechanical energy); chemical causes. Mechanisms of xenobiotic biotransformation. Cell pathology: adaptation (atrophy/hypertropy, metaplasy, neoplasy) and death (necrosis and apoptosis). Innate immunity: cells and molecules, local and systemic inflammation, acute and chronic, histological variants of inflammation, tissue damage repair and regeneration. Adaptive Immunity: generation, education and function of B and T lymphocytes Type I hypersensitivity Mention of immune system’s diseases (immunodeficiencies, autoimmunity and auto-inflammatory diseases) Mention of Hematopoietic stem cells (HSC) and HSC transplants Atherosclerosis and mention of cardiovascular disease and rheumatic fever Oncology: benign and malign neoplasms, the abnormal metabolism of cancer cells, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment. Immune responses against cancer, Natural killer cells, tumor escape mechanisms, tumor-associated inflammation. Environmental causes of cancer: physical, chemical and biological carcinogenesis. Optical microscope evaluation of pathologic tissues (different types of inflammation and cancer). RECOMMENDED READING/BIBLIOGRAPHY Robbins & Cotran Pathologic Basis of Disease, Elsevier Abbas & Lichtman Cellular and Molecular Immunology, Elsevier The didactic material is available in pdf format for download (https://www.aulaweb.unige.it). TEACHERS AND EXAM BOARD CRISTINA BOTTINO Ricevimento: By appointment Email: Cristina.Bottino@unige.it ROBERTA RICCIARELLI Ricevimento: By appointment by email: ricciarelli@medicina.unige.it Exam Board CRISTINA BOTTINO (President) ROBERTA RICCIARELLI (President) LESSONS LESSONS START 2nd semester, 2nd year Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The students are evaluated in an oral examination. Two professors examine each student about any of the subject of the course program. ASSESSMENT METHODS The oral examination consists in several questions, starting from more general questions to more precise ones, in order to assess the knowledge of the students. Students must know the requested pathogenetic mechanisms and demonstrate the ability to connect different subjects of the program. Exam schedule Data appello Orario Luogo Degree type Note 08/01/2019 09:00 GENOVA Orale 22/01/2019 09:00 GENOVA Orale 12/02/2019 09:00 GENOVA Orale 11/06/2019 09:00 GENOVA Orale 25/06/2019 09:00 GENOVA Orale 16/07/2019 09:00 GENOVA Orale 10/09/2019 09:00 GENOVA Orale 24/09/2019 09:00 GENOVA Orale FURTHER INFORMATION The didactic material is available in pdf format for download (https://www.aulaweb.unige.it) Students can contact the teachers by mail (information, appointment)
