CODE 80452 ACADEMIC YEAR 2018/2019 CREDITS 8 cfu anno 4 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/08 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2015/2016) GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2015 MATHEMATICS (PCT)(MD) 55402 2015 ANALYTICAL CHEMISTRY (PCT)(MD) 55403 2015 PHYSICS (PCT)(MD) 55404 2015 PHYSICAL CHEMISTRY (MD) 60821 2015 ORGANIC CHEMISTRY I (PCT)(MD) 60822 2015 DRUGS ANALYSIS WITH PRACTICE 80443 2015 DRUGS ANALYSIS WITH PRACTICE 80445 2015 TEACHING MATERIALS AULAWEB AIMS AND CONTENT LEARNING OUTCOMES The course consists of a theoretical part and a practical section (laboratory exercises). It aims to provide basic knowledge on the main instrumental analytical methods used in the quali-quantitative analysis of medicinal substances, pure or contained in pharmaceutical preparations. Knowledge on theoretical principles, applications in the pharmaceutical analysis and essential technical aspects of the instrumentation are provided in addition to theoretical and practical knowledge of modern methods of extraction from complex matrices. SYLLABUS/CONTENT Introduction and classification of instrumental analytical methods Analytical instrumentation: signal units; detectors; signal integrators and computers. Significant figures: precision, sensitivity, accuracy, limit of detection and quantitation, selectivity.Signal and noise. Spectroscopy Electromagnetic radiation. Interaction with matter: absorption and amission. Lambert-Beer’s law. Instrumentation: radiation sources, wavelength selectors, detectors. Visible-ultraviolet molecular spectroscopy. Qualitative and quantitative applications. Fluorescence and phosphorescence. Characteristcs of methods. Qualitative and quantitative applications. Derivatization methods. Atomic absorption and emission spectroscopy. Atomizers. Flame atomization, plasma emission. Pharmaceutical applications. Chromatography Classification of chromatographical methods. Theory of separation processes: Van Deemter’s equation. Efficiency and resolution. Gas chromatography. General basics. Instrumentation. Hyphenated techniques. Qualitative and quantitative applications. Derivatization methods. High-performence liquid chromatography. General basics. Stationary and mobile phases. Instrumentation. Qualitative and quantitative applications. Derivatization methods. Ion chromatography and size-exclusion chromatography. Capillary electrophoresis General basics. Instrumentation, Pharmaceutical applications. Sample preparation Supercritical fluid extraction: general basics, instrumentation, applications. Solid-phase extraction: general basics, instrumentation and material, applications. Chiral drugs analysis. Enantiomeric mixtures. Chiral chromatographical methods. Chiral Phases. RECOMMENDED READING/BIBLIOGRAPHY - Chimica Analitica Strumentale - Holler, Skoog, Crouch.- EdiSES 2009 - Fondamenti di chimica analitica – Skoog, West – EdiSES 2015 - Analisi farmaceutica - D. G. Watson - Edra 2014 TEACHERS AND EXAM BOARD BRUNO TASSO Ricevimento: Daily by appointment (phone or email). Exam Board BRUNO TASSO (President) CHIARA BRULLO ANDREA SPALLAROSSA EXAMS Exam schedule Data appello Orario Luogo Degree type Note 17/06/2019 09:00 GENOVA Orale 02/07/2019 09:00 GENOVA Orale 19/07/2019 09:00 GENOVA Orale 06/09/2019 09:00 GENOVA Orale 20/09/2019 09:00 GENOVA Orale 24/01/2020 09:00 GENOVA Orale 12/02/2020 09:00 GENOVA Orale
