CODE 62272 ACADEMIC YEAR 2018/2019 CREDITS 6 cfu anno 1 BIOLOGIA MOLECOLARE E SANITARIA 9015 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/06 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester MODULES Questo insegnamento è un modulo di: CELL AND DEVELOPMENTAL BIOLOGY TEACHING MATERIALS AULAWEB OVERVIEW The developmental biology studies the events from fertilization to adult and is also the basis for the study of biological evolution that, driven by selection, proceeds according to the constraints of development. The course deepens the determination of body axes in different model organisms, both invertebrates and vertebrates, and the differentiation of structures derived from the three embryonic layers with reference also to the adult stem cells. AIMS AND CONTENT AIMS AND LEARNING OUTCOMES Knowledge of the molecular and cellular bases of the development of the main model organisms (Drosophila, Caenorhabditis elegans, sea urchin, ascites, anfios, zebrafish, xenopus, chicken, mouse, man), with particular attention to the determination of the body axes. Insights into the development of ectodermal, mesodermic and endodermic derivatives. In particular, the evolutionary aspects of neurogenesis and cell differentiation will be investigated. TEACHING METHODS Oral lectures SYLLABUS/CONTENT Cellular and molecular mechanisms of the development of Chordates. Primary induction in Chordates: Nieuwkoop center, Spemann organizer, vertical and horizontal signals, mesoderm regionalization (zebrafish, Xenopus, chicken, mouse, man). Ascidian cell lineage and amphioxus development. Determination of body axes. Cellular and molecular mechanisms of neurogenesis in invertebrates (C.elegans and Drosophila). Determination of neural cell fate, symmetric and asymmetric divisions and cellular polarity. Neurogenesis in chordates. Neurogenesis in ascidians and amphioxus. Neural induction. Neural crest. Regionalization of CNS in chordates. Differentiation of cerebral and cerebellar cortex. Evolutionary aspects of neurogenesis. Mechanisms of cell differentiation. Adult stem cells in ectodermal, mesodermal and endodermic tissues. RECOMMENDED READING/BIBLIOGRAPHY Gilbert S.F.: Biologia dello sviluppo. IV ed.it. Zanichelli Editore Wolpert L. et al.: Biologia dello sviluppo. II ed.it. Zanichelli Editore. Sanes D.H. et al.: Lo sviluppo del sistema nervoso. Ed.it. Zanichelli Editore Power Point presentations and selected reviews will be delle lezioni e altro materiale bibliografico quali reviews will be available to the students through Aulaweb. TEACHERS AND EXAM BOARD MARIO PESTARINO Exam Board SARA FERRANDO (President) MARIO PESTARINO (President) TIZIANA BACHETTI SIMONA CANDIANI LESSONS LESSONS START II semester Class schedule DEVELOPMENTAL BIOLOGY II EXAMS Exam schedule Data appello Orario Luogo Degree type Note 28/01/2019 09:00 GENOVA Orale 11/02/2019 09:00 GENOVA Orale 17/06/2019 09:00 GENOVA Orale 08/07/2019 09:00 GENOVA Orale 22/07/2019 09:00 GENOVA Orale 02/09/2019 09:00 GENOVA Orale 16/09/2019 09:00 GENOVA Orale