CODE 98319 ACADEMIC YEAR 2018/2019 CREDITS 2 cfu anno 2 BIOLOGIA ED ECOLOGIA MARINA 10723 (LM-75) - GENOVA 2 cfu anno 2 BIOLOGIA ED ECOLOGIA MARINA 10723 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/14 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester TEACHING MATERIALS AULAWEB OVERVIEW The study of marine pharmaceuticals resources, clinical application of marine bioactive drugs and material is an emerging discipline. In the last years, several drugs were developed and placed in marketing from marine natural products and many marine-derived chemicals are investigated in preclinical and clinical research. AIMS AND CONTENT LEARNING OUTCOMES The aim of the course is to provide knowledge on the numerous pharmacological potentialities, on the mechanisms of action and the molecular targets of natural substances isolated from the marine world. The world research on natural drugs has focused its interest on this topic. The basic knowledge of modern pharmacology and toxicology will be provided to fully understand the potential and impact of these molecules. The marine toxins and their effects on a living organism will be explored too. AIMS AND LEARNING OUTCOMES The main objective is to acquire knowledge of natural substances isolated from the marine world, their use in clinical or preclinical pharmacology, their mechanisms of action and molecular targets. This objective will be achieved based on the elemental concepts of modern pharmacology and toxicology. The students could consider the sea as a resource to protect and monitor. The marine ecopharmacology and marine toxins will also be the subject of the course, considering their effects in a living organism. TEACHING METHODS Frontal lessons with an in-depth analysis of the program. Therefore, the frequency of lessons is recommended. SYLLABUS/CONTENT Essential lexicon in Pharmacology and Toxicology: active substances (drugs; medicinal preparations; medicinal herbs; placebo), xenobiotics, toxicological agent. The scope of the field. Elements of Pharmacology and Toxicology: Activity, Safety, Efficacy in preclinical and clinical studies; ED50 LD50; Therapeutic Index and Margin of Safety, NOEL, LOEL Marine drugs: targets, pharmacological activity, pharmacokinetics, toxicity and clinical uses Marine Biotoxins Ecopharmacology and ecopharmacovigilance: drugs in the sea RECOMMENDED READING/BIBLIOGRAPHY Golan DE e altri - Principi di Farmacologia – Casa Editrice Ambrosiana Rang HP, Dale MM, RitterJM, Flower RJ - Farmacologia - Ed. Elsevier Masson Howland RD, Mycek MJ – Le basi della farmacologia – Ed Zanichelli Notes of Lessons TEACHERS AND EXAM BOARD CHIARA CERVETTO Ricevimento: By appointment Exam Board CHIARA CERVETTO (President) MANUELA MARCOLI LESSONS LESSONS START II semester Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION To assess student’s achievement of learning, the examination will be an oral exam (30 minutes), always in presence of the Commission consisting of at least of two professors (or sometimes in presence of a professor and an expert subject designated by the CCS). ASSESSMENT METHODS The Commission will verify the achievement of learning outcome with high accuracy. During the examination, the Commission will collect information about the knowledge of the topics and their understating, the communication skills as well as the connection and reasoning within topics of the course. When the educational objectives will be not achieved, the student will be invited to verify better the knowledge and to use supplemental explanations contacting the professor.
