CODE 61786 ACADEMIC YEAR 2019/2020 CREDITS 6 cfu anno 1 BIOLOGIA MOLECOLARE E SANITARIA 9015 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/09 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester PREREQUISITES Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Molecular and health biology 9015 (coorte 2019/2020) CLINICAL PATHOLOGY 61775 Molecular and health biology 9015 (coorte 2019/2020) CLINICAL BIOCHEMISTRY 80678 TEACHING MATERIALS AULAWEB OVERVIEW The course explores the study of the mechanisms of regulation of metabolic homeostasis in humans, addressing the regulation of the various functions by the nervous system and the endocrine system and highlighting the existing integrations between the various systems. AIMS AND CONTENT LEARNING OUTCOMES The course aims to provide in-depth knowledge on physiological regulation in humans, highlighting and enhancing the relationships of connection and interdependence between processes and physiological mechanisms. AIMS AND LEARNING OUTCOMES Participation in the course will allow students of the Degree in Molecular and Health Biology to deepen the knowledge of Physiology learned during the Bachelor's Degree, with specific reference to humans. This knowledge is necessary for the career opportunities of the biologist in health and research. The course aims to provide a complete vision of Human Physiology and allows the student to acquire detailed information on how the different organs of the human body work, on the dynamic integration of the organs in systems, on the general mechanisms of homeostatic control under normal conditions and adaptation, with a specific attention to the molecular mechanisms involved. Taking advantage of the physiological bases, hints of pathophysiology will be provided. The student must be able to: • know how the human organism work at the molecular, cellular, organ and system levels. • Acquire an integrated view of the physiological mechanisms that regulate homeostasis and adaptation processes in humans. • know how the human organism works as a whole. • Understanding simple pathophysiological situations resulting from the loss of homeostatic regulation. • Highlight the link between structure and function at the level of organs and systems. • Acquire a correct terminology in the pathophysiological field. PREREQUISITES The following basic knowledge of physiology and pathology is required to effectively address the teaching content: 1) animal physiology, 2) general pathology. TEACHING METHODS The teaching method includes 24 lectures of 2 hours each. Lessons are delivered through multimedia presentations. Frequency is highly recommended. SYLLABUS/CONTENT Recall of physiology of the nervous system and of the endocrine system. Endocrine system dysfunction: hypofunction, hyperfunction, sensitivity deficit. The hypothalamus-pituitary system. Hypothalamus: structure and functions. Posterior pituitary: structure and functions. Neuroendocrine reflexes. Vasopressin: osmotic regulation, pressure / volume regulation, insipid diabetes. Oxytocin: childbirth and lactation. Anterior pituitary: structure and functions. The pituitary portal system. The hypothalamic releasing and inhibiting factors. The hormones of the anterior pituitary. Short and long feedback. Prolactin and lactation regulation. Endocrine growth regulation: the GH-IGF-IGFBP system. Hypothalamus-pituitary-thyroid axis. Regulation of body temperature. Stress response: nervous arm and endocrine arm. Effects of catecholamines. Effects of cortisol. Allostasis and allostatic load. Stress and dysmetabolism. Stress, immune system and inflammation. Emotions and stress response. Integration between biological and psychological and social systems (psychoneuroendocrinoimmunology: PNEI). Pre and perinatal stress. The role of the intestinal microbiota. Steroidogenesis in the adrenal cortex. Hormonal regulation of ion and water balance. Renin-angiotensin-aldosterone system. Effects of aldosterone. Natriuretic peptides. Hormonal regulation of the reproductive function. Steroidogenesis in the gonads. Hormonal regulation of sexual differentiation. Hypothalamus-pituitary-gonadal axis. Testis: Sertoli cells, Leydig cells. Hypotheses on the factors influencing the onset of puberty. Ovary: ovarian cycle, theca cells and granulosa cells. Hormonal contraception. Pregnancy. Menopause. Adrenarche and adrenal androgens. Hormonal regulation of glycemic homeostasis. Endocrine function of the pancreas. Liver structure: microscopy. The hepatic lobule. Characteristics of the different cell types of the liver: hepatocytes, sinusoidal endothelial cells, Kupffer cells and stellate cells. Role of the liver in the metabolism of carbohydrates, lipids and proteins. Cooperation of liver cells in normal physiological functions and in metabolic alterations. Liver function markers. Alterations of normal hepatic architecture: clinical forms and responses to acute and chronic hepatic injury. Partial hepatectomy and hepatic regeneration: cascade activation of early and late events. Hormonal regulation of calcium homeostasis. Regulation of intracellular calcium concentration. Parathormone: effects on bone and kidney. Vitamin D: biosynthesis and introduction with diet, effects on intestine, bone, immune system, rickets and osteomalacia. Calcitonin. Biorhythms. Melatonin. The sleep-wake cycle. Memory and learning. Molecular dysfunctions in neural communication. RECOMMENDED READING/BIBLIOGRAPHY -Silverthorn Fisiologia CEA - Sherwood Fisiologia Umana Zanichelli The multimedia material used during the lessons will be made available on AulaWeb, together with any useful articles for the deepening of certain topics. TEACHERS AND EXAM BOARD ILARIA DEMORI Ricevimento: Agreed directly with the teacher. Make an appointment by email: idemori@unige.it. Office: DISTAV; 5 floor, Palazzo delle Scienze, corso Europa 26, 16132 Genoa Tel: 0103538246 Exam Board ILARIA DEMORI (President) BRUNO PIETRO BURLANDO ELENA GRASSELLI ADRIANA VOCI LESSONS LESSONS START For lessons start and timetables, please see the following link: http: //www.distav.unige.it/ccsbio/orario-lezioni-bms Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The exam consists of an oral interview of about thirty minutes, conducted by a commission consisting of at least two members, during which the student will have to explain some of the topics covered in class. At least 2 calls will be available in the winter session (January-February) and 5 calls in the summer session (June, July, September). ASSESSMENT METHODS The Commission verifies the achievement of the educational objectives by asking different questions related to the program actually carried out during the lessons. Details on the degree of in-depth knowledge for each topic will be provided during the lessons. The oral examination allows to evaluate the knowledge of the fundamental elements of the subject and the ability to link the various topics. During the interview the Commission will verify if the student has acquired the ability to apply the theoretical concepts to simple concrete contexts. The quality of the speech and the use of the correct specialized scientific terminology will also be evaluated. When the training objectives are not achieved, the student is invited to better verify his / her knowledge and possibly to make use of further explanations by contacting the teacher in charge of the course. Exam schedule Data appello Orario Luogo Degree type Note 30/01/2020 09:00 GENOVA Orale 11/02/2020 09:00 GENOVA Orale 10/06/2020 09:00 GENOVA Orale 14/07/2020 09:00 GENOVA Orale 01/09/2020 09:00 GENOVA Orale 15/09/2020 09:00 GENOVA Orale FURTHER INFORMATION Regular frequency is strongly recommended.