The course gives students the fundamental elements of pathophysiology, which are essential for the successive comprehension of clinical medical sciences.
Physiopathology is a branch of medicine that combines physiology and pathology especially in the study of altered bodily function in disease. The learning outcome is the knowledge of the main physiopathological mechanisms of organs and systems, in order to recognize the mechanisms and causes of their malfunction, and to be able to interpret the symptoms, which will be exposed to the students in the successive clinical courses
Knowledge of the main physiopathological mechanisms of organs and systems, with particular regard to blood, liver, kidney, respiratory and digestive systems, some aspects of endocrinology and metabolism, and the physiopathology of neoplasms.
basic knowledge in anatomy, histology, biochemistry, immunology and physiology
Lectures, with any possible dialectic interaction with students
In case of sanitary emergency, lessons will switch to remote learning
Hematopoiesis, hematopoietic stem cell (HSC), mesenchimal stem cell (MSC), HSC transplant (HSCT).
Erythropoiesis, classification and examples of anemia: aplastic, paroxysmal nocturnal nemoglobinuria (PNH), immune hemolytic, deficiency (Fe, B12 and B9), drugs-mediated, secondary to chronic disorders.
Hemostasis and examples of hemostasis disorders (endothelium, platelets or coagulation factors abnormalities).
Oncology: benign and malign neoplasms, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Hematological malignances: classification and examples of myeloid and lymphoid neoplasms. Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment. Immune responses against cancer, tumor escape mechanisms, tumor-associated inflammation.
Pathogenesis and consequences of dyslipidemias. Atherosclerosis, cardiovascular diseases, Acute rheumatic fever (ARF), essential and secondary hypertension.
Classification of renal diseases, and acute and chronic renal failure. Hydro-electrolytic balance, in particular sodium and potassium. Acid base balance and its alterations.
Pathogenesis and pathophysiology of diabetes mellitus.
Pathophysiology of lipoprotein metabolism
Examples of nitrogen metabolism: phenylketonuria, hyperhomocystinemias, gout
Pathophysiology of the respiratory system.
Pathophysiology of the liver and the biliary tract: acute and chronic hepatitis, cirrhosis and ascites, hepatic failure, portal hypertension, cholestasis, icterus, systemic effects of liver damage
Liver metabolic diseases: Alpha-1 antitrypsin deficiency Hemochromatosis and Hemosiderosis Wilson disease Overview of most common digestive disorders Overview of most common pancreatic disorders
Robbins & Cotran Pathologic Basis of Disease, Elsevier
The didactic material is available in pdf format for download (https://www.aulaweb.unige.it). The aim of the course is also to familiarize students with online biomedical scientific literature (https://www.ncbi.nlm.nih.gov/pubmed)
Ricevimento: By appointment Email: Cristina.Bottino@unige.it
Ricevimento: For appointments, contact the Professor via email at: Nicola.Traverso@unige.it. The teacher's office is located in the General Pathology Section of DIMES, Via Leon Battista Alberti 2, 1st floor, 16132 Genoa
Ricevimento: students can send email to make an appointment; anna.maria.bassi@unige.it
Ricevimento: The reception of the students is agreed from time to time, according to the needs and deadlines, by e-mail to the following address: Cinzia.Domenicotti@unige.it General Pathology Section - DIMES via LB Alberti 2- Genoa tel +39 010 3538830
CRISTINA BOTTINO (President)
MARIA ADELAIDE PRONZATO (President)
NICOLA TRAVERSO (President)
ANNA MARIA BASSI
CINZIA MARIA DOMENICOTTI
1st semester, 3rd year
Oral exams. The students are evaluated by two professors about any of the subject of the course program.
On line exams in case of sanitary emergency
The oral examination consists in several questions, starting from more general questions to more precise ones, in order to assess the knowledge of the students. Students must know the main physiopathological mechanisms of the selected organs/systems and demonstrate the ability to connect different subjects of the program.
The didactic material is available in pdf format for download (https://www.aulaweb.unige.it)
Students can contact the teachers by mail (information, appointment)
