CODE 65529 ACADEMIC YEAR 2020/2021 CREDITS 8 cfu anno 2 SCIENZE BIOLOGICHE 8762 (L-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/06 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Biological Sciences 8762 (coorte 2019/2020) INSTITUTIONS OF MATHEMATICS 52344 2019 CYTOLOGY AND HISTOLOGY AND LABORATORY 65513 2019 GENERAL AND INORGANIC CHEMISTRY WITH LABORATORY 65521 2019 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Biological Sciences 8762 (coorte 2019/2020) BIOLOGICAL CHEMISTRY AND LABORATORY 65531 TEACHING MATERIALS AULAWEB OVERVIEW Organic Chemistry and Laboratory (CHIMORG, code 65529) is worth 8 credits and takes place in the first semester, years: 2nd LT SB. Classes are held in Italian. For enrolled students, the teaching material is available on AulaWeb. AIMS AND CONTENT LEARNING OUTCOMES The aim of the course is to provide knowledge of Organic Chemistry indispensable for the understanding, from a chemical point of view, of the properties of compounds of biological interest. AIMS AND LEARNING OUTCOMES Remember the concepts related to atoms, electronegativity and chemical bonds Understand the concepts of polar covalent bonding, hybridization, sigma and pi bond, isomerism, resonance Apply these concepts to the construction of organic molecules, to the identification of their arrangement in the space, to the recognition of the functional groups and to the assignment of the IUPAC name Analyze the organic molecules on the basis of their structure, recognizing their acidity / basicity, nucleophilic / electrophilic character; identify six different types of chemical reactions Evaluate the reactivity of organic molecules based on their structure and the environment in which they are located Create new substances by reaction of simple organic molecules TEACHING METHODS Frontal lessons Laboratory activities SYLLABUS/CONTENT Atoms and molecules. Hybridization of the carbon atom. Theory of resonance. Lewis formulas. Acids and Bases. Alkanes and cycloalkanes. Nomenclature and properties. Conformations Alkenes, cycloalkenes, polyenes. Nomenclature and properties. Isomerism E / Z Alkyne. Nomenclature and properties. Benzene and aromatic compounds. Nomenclature and properties Stereoisomery and enantiomery. Configurations R / S Halogen derivatives. Alcohols. Nucleophilic substitution reactions and elimination Carbonyl compounds, aldehydes and ketones. Carboxylic acids and acyl derivatives. Amines; purine and pyrimidine bases Lipids; triglycerides. Chemical and physical characteristics. Phospholipids. Terpenes. Monosaccharides: aldoses and ketoses; projections, hemiacetalic forms; reactivity. Mono- and polysaccharides α-Amino acids: properties. Peptide bond. Structure of proteins. Nucleic acids, nucleosides and nucleotides. Laboratory practical tests: Isolation of an essential oil by distillation Extraction, chromatographic separation and spectrophotometric analysis of natural pigments Resolution of a racemic mixture - polarimetry Recognition essays for major natural substances RECOMMENDED READING/BIBLIOGRAPHY Klein “FONDAMENTI DI CHIMICA ORGANICA”, 2016, Pearson Italia, Milano-Torino Brown “INTRODUZIONE ALLA CHIMICA ORGANICA”, 2005 (2001, 1999), Edises, Napoli McMurry “FONDAMENTI DI CHIMICA ORGANICA”, 2011, Zanichelli, Bologna TEACHERS AND EXAM BOARD ANDREA BASSO Ricevimento: on appointment Exam Board ANDREA BASSO (President) CINZIA TAVANI LARA BIANCHI (President Substitute) LISA MONI (Substitute) LESSONS Class schedule ORGANIC CHEMISTRY AND LABORATORY EXAMS EXAM DESCRIPTION The exam consists of a written test in which the students will have to answer open questions on the following topics: nomenclature and isomerism acidity and basicity reactivity biomolecules laboratory activities Each question is associated with a maximum score, which takes into account the difficulty of the question itself; the written test is considered passed when the overall score is at least 18/30; students who pass the test will have an oral examination which will consist of a series of questions about the theory and laboratory activity ASSESSMENT METHODS The exam consists of a written test and an oral exam. The written test is generally organized on more open-ended questions with scores which take account of various difficulties, while the oral exam, which can be accessed only after passing the written exam, consists of an interview. Both written and oral tests are based on the program carried out in class to evaluate the achievement of educational goals. The oral examination is always conducted by a commission made up of at least two professors (or in limited cases as a tenured professor and an expert on the subject so designated by CCS) and has a reasonable duration. The Commission, appointed in this way, you can verify with high accuracy to achieve the educational objectives of teaching by putting different questions related to the program actually carried out during the course lessons. When the educational objectives are not achieved, the student is encouraged to better verify his knowledge and possibly to make use of further explanations by contacting the owner of the teacher teaching the course. Exam schedule Data appello Orario Luogo Degree type Note 25/01/2021 09:00 GENOVA Scritto + Orale 08/02/2021 09:00 GENOVA Scritto + Orale 14/06/2021 09:00 GENOVA Scritto + Orale 12/07/2021 09:00 GENOVA Scritto + Orale 06/09/2021 09:00 GENOVA Scritto + Orale FURTHER INFORMATION Prerequisites The examination must follow the one of General and Inorganic Chemistry with Laboratory. Knowledge of derivatives, integrals, logarithmic and exponential functions. Knowledge of Thermodynamics, Electromagnetism, Optics. Good knowledge of General and Inorganic Chemistry Frequency Recommended for lectures, compulsory for laboratory work and preliminary lessons to it