The course aims to provide students with basic, molecular, genetic and cellular knowledge to understand the fundamental mechanisms of response to cellular damage and adaptive response: hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia, cellular aging, necrosis and apoptosis. The course is focused on etiology, cellular pathology,innate and adaptive immune response.
The students will also acquire skills to understand the defense mechanisms associated with the inflammatory and immunological responses. It will be deepen the organization of the immune system, the different cells involved, the mechanisms of antigen recognition, differentiation and activation of B and T lymphocytes, development of effector response. Will investigate the natural and acquired mechanisms of inflammation and immune against bacterial and viral pathogens, the underlying mechanisms of tolerance to their constituents and the main immune mechanisms of pathological relevance.
The course aims to provides the molecular and cellular knowledge to understand the mechanisms of cell damage, free radical pathology, cellular response, and defense mechanisms that occur as a result of a stressor stimulus that can lead to morphological and functional alteration. Students will acquire theoretical and practical concepts regarding General Pathology and the mechanisms underlying the onset of cellular damage that leads to a disease.
Prerequisites: sound knowledge of Cytology, Hystology, Physiology, Biochemistry and Molecular Biology
oral lecture with slide presentations.
Please refer to the specific AulaWeb instance of the course for any updates due to changes in the health and epidemiological status.
CELLULAR RESPONSES TO STRESS AND TOXIC INSULTS: ADAPTATION, INJURY, AND DEATH
Mechanisms of cell injury. Reversible and irreversible injury
Necrosis and apoptosis
Adaptations of cellular growth and differentiation
Heat shock proteins
Hypertrophy – Hyperplasia – Atrophy - Metaplasia
Free-radicals and reactive species and antioxidant defences
ASPECIFIC DEFENCES
- Acute inflammation:
Reactions of blood vessels in acute inflammation
Reactions of leukocytes in inflammation
Termination of the acute inflammatory response
Stimuli for acute inflammation
Mediators of inflammation: Cell-derived mediators and Plasma protein-derived mediators
Outcomes of acute inflammation
Morphologic patterns of acute inflammation
- Chronic inflammation
Causes of chronic inflammation
Morphologic features
Role of macrophages in chronic inflammation
Other cells in chronic inflammation
Granulomatous inflammation
- Systemic effects of inflammation
- Tissue renewal, regeneration, and repair
SPECIFIC DEFENCES:
Antigens and Antibodies
Component of the innate Immune system (epithelial barriers. Phagocitosis, Natural killer cells
Circulating proteins of innate immunity: The Complement System; Cytokines
Role of innate immunity in stimulating adaptive immune responses
Cells and tissues of the adaptive immune system
The major histocompatibility complex
T-Cell Receptor
T-Cell Maturation, Activation, and Differentiation
B-Cell Generation, Activation, and Differentiation
Organization and Expression of Immunoglobulin Genes
Immunological tolerance
Effector mechanisms of humoral immunity
Effector mechanisms of Cell-Mediated Cytotoxic Responses
Hypersensitivity Reactions
Tolerance and Autoimmunity
Congenital and acquired immunodeficiencies
Transplantation Immunology
Immune Response to Infectious Diseases
Vaccines
Robbins & Cotran Pathologic Basis of Disease 9th Edition Authors: Vinay Kumar Abul Abbas Jon Aster
Cellular and Molecular Immunology 8th Edition Authors Abul Abbas Andrew H. Lichtman Shiv Pill
Ricevimento: students can send email to make an appointment; anna.maria.bassi@unige.it
ANNA MARIA BASSI (President)
ANNA LISA FURFARO
MARIAPAOLA NITTI (President Substitute)
BARBARA MARENGO (Substitute)
SUSANNA PENCO (Substitute)
GENERAL PATHOLOGY IMMUNOLOGY AND LABORATORY
oral examination: the student will have to answer correctly 3 questions regarding the exam. to pass the examination, a sufficient response will be required for each of the 3 covered topics.
For the final evaluation, the committee will evaluate the following requirements: level of knowledge of the subjects covered by the questions, exposure skills, reasoning and the ability to connect to topics discussed in the course, as well those of related preparatory courses of the degree. overcoming the test on the topics discussed in the laboratory.
Slides and more detailed informations on the arguments will be offer by aulaweb
