CODE 66685 ACADEMIC YEAR 2020/2021 CREDITS 6 cfu anno 2 BIOLOGIA MOLECOLARE E SANITARIA 9015 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Molecular and health biology 9015 (coorte 2019/2020) CLINICAL PATHOLOGY 61775 TEACHING MATERIALS AULAWEB OVERVIEW Cellular and Molecular Pathology (6 CFU) is a mandatory exam in the 2nd year of the MHB course (sping period) AIMS AND CONTENT LEARNING OUTCOMES This course aims at providing deep knowledge of the molecular mechanisms underlying the most important human diseases. The alterations of structures, functions and control mechanisms in degenerative pathologies as well as in neoplastic transformations will be studied at molecular, cellular and tissue level. Students will be able to use and apply this knowledge both in research activity and in clinical laboratory AIMS AND LEARNING OUTCOMES The deep knowledge of molecular mechanisms underlying the loss of homeostatic ability in tissues and the pathogenesis of the main human diseases is fundamental for the students and will be crucial in student's research activity and in clinical laboratory activity as well. Specifically, the student will be able to - discriminate between the alterations of cells and tissues found in the main human pathologies and identify the molecular alterations that characterize them, - describe molecular or cellular alterations common to different pathologies, - classify the different nosological entities, - acquire specific and specialized terminology PREREQUISITES The students are assumed to know the topics covered by the courses of biochemistry, human anatomy and physiology is fundamental to approach the course, in particular an in-depth knowledge of signal transduction, protein synthesis, mitochondrial functions, cell cycle, heart and blood vessels, lymphatic system, liver, pancreas, blood glucose control, blood functions, hemostatic control. TEACHING METHODS The course consists of lectures delivered through multimedia presentations. SYLLABUS/CONTENT Cell adaptations: modifications of cell growth and differentiation. Atrophy, hypoplasia, hypertrophy, metaplasia. Cell injury: hypoxic/ischemic damage, chemical damage, free radical damage. Cellular responses to stress: alteration of lysosoms, mitochondria, endoplasmic reticulum, cytoskeleton. Cell death: necrosis/apoptosis Cell and tissue degenerations: primary dysfunctions/intracellular accumulations/extracellular accumulations/pathological pigmentations. Liver pathologies: Steatosis, Fibrosis, Cirrhosis Hemosiderosis, Wilson Disease. Amyloidosis Atherosclerosis: pathogenesis and sequelae Hemostasis and thrombosis Bleeding diathesis: congenital and acquider disorders. CID Vascular pathologies: edema, embolism, thrombosis, infarction, shock Anemias (congenital and acquired), leucopoenia, leukocytosis, leukaemia Diabetes: pathogenesis and sequelae Nervous system pathologies: epilepsy, multiple sclerosis, tetanus (overview) Parkinson Disease and Alzheimer Disease: histological features and pathogenetic mechanisms Neoplasia: Tumor atypias. Metastasis Benign tumors and cancers. histological classification. TNM system Molecular mechanisms of carcinogenesis. Oncogenes and tumor suppressor genes Carcinogenic compounds, radiations, biological agents Immune system and cancer (overview) Angiogenesis and cancer (overview) RECOMMENDED READING/BIBLIOGRAPHY All the slides used during the lectures and other teaching material will be available on AulaWeb at the end of each cycle of lessons together with other selected papers in pdf format. The suggested books are available together with other books for further study at the teacher office. Recommended texts for any further information: Robbins e Cotran: Le basi patologiche delle malattie (ELSEVIER) Rubin: Patologia (Casa Ed. Ambrosiana) M. Pontieri: Patologia generale/ Fisiopatologia Generale – PICCIN TEACHERS AND EXAM BOARD MARIAPAOLA NITTI Ricevimento: Anytime by appointment Exam Board MARIAPAOLA NITTI (President) ANNA MARIA BASSI ANNA LISA FURFARO (President Substitute) LESSONS LESSONS START For lessons start and timetable go to the following link For lessons start and timetable go to the following link https://easyacademy.unige.it/portalestudenti/ Class schedule MOLECULAR AND CELLULAR PATHOLOGY EXAMS EXAM DESCRIPTION The oral examination consists of the answer to questions asked by the teacher on topics covered during the course. ASSESSMENT METHODS Three questions will be asked on the topics covered during the Course. To get a passing-grade for each question is mandatory to pass the exam. The final evaluation will take into account student ability to analyse in depht the topics, to use the specialistic vocabulary and to logically connect different aspects of molecular pathology. Exam schedule Data appello Orario Luogo Degree type Note 28/01/2021 10:00 GENOVA Orale 12/02/2021 10:00 GENOVA Orale 08/04/2021 10:00 GENOVA Orale 18/06/2021 10:00 GENOVA Orale 08/07/2021 10:00 GENOVA Orale 22/07/2021 10:00 GENOVA Orale 17/09/2021 10:00 GENOVA Orale FURTHER INFORMATION Regular attendance at lectures is strongly recommended.
