Cellular and Molecular Pathology (6 CFU) is a mandatory exam in the 2nd year of the MHB course (sping period)
This course aims at providing deep knowledge of the molecular mechanisms underlying the most important human diseases. The alterations of structures, functions and control mechanisms in degenerative pathologies as well as in neoplastic transformations will be studied at molecular, cellular and tissue level. Students will be able to use and apply this knowledge both in research activity and in clinical laboratory
The deep knowledge of molecular mechanisms underlying the loss of homeostatic ability in tissues and the pathogenesis of the main human diseases is fundamental for the students and will be crucial in student's research activity and in clinical laboratory activity as well. Specifically, the student will be able to
- discriminate between the alterations of cells and tissues found in the main human pathologies and identify the molecular alterations that characterize them,
- describe molecular or cellular alterations common to different pathologies,
- classify the different nosological entities,
- acquire specific and specialized terminology
The students are assumed to know the topics covered by the courses of biochemistry, human anatomy and physiology is fundamental to approach the course, in particular an in-depth knowledge of signal transduction, protein synthesis, mitochondrial functions, cell cycle, heart and blood vessels, lymphatic system, liver, pancreas, blood glucose control, blood functions, hemostatic control.
The course consists of lectures delivered through multimedia presentations.
Cell adaptations: modifications of cell growth and differentiation. Atrophy, hypoplasia, hypertrophy, metaplasia.
Cell injury: hypoxic/ischemic damage, chemical damage, free radical damage.
Cellular responses to stress: alteration of lysosoms, mitochondria, endoplasmic reticulum, cytoskeleton.
Cell death: necrosis/apoptosis
Cell and tissue degenerations: primary dysfunctions/intracellular accumulations/extracellular accumulations/pathological pigmentations.
Liver pathologies: Steatosis, Fibrosis, Cirrhosis
Hemosiderosis, Wilson Disease.
Amyloidosis
Atherosclerosis: pathogenesis and sequelae
Hemostasis and thrombosis
Bleeding diathesis: congenital and acquider disorders. CID
Vascular pathologies: edema, embolism, thrombosis, infarction, shock
Anemias (congenital and acquired), leucopoenia, leukocytosis, leukaemia
Diabetes: pathogenesis and sequelae
Nervous system pathologies: epilepsy, multiple sclerosis, tetanus (overview)
Parkinson Disease and Alzheimer Disease: histological features and pathogenetic mechanisms
Neoplasia:
Tumor atypias. Metastasis
Benign tumors and cancers. histological classification. TNM system
Molecular mechanisms of carcinogenesis. Oncogenes and tumor suppressor genes
Carcinogenic compounds, radiations, biological agents
Immune system and cancer (overview)
Angiogenesis and cancer (overview)
All the slides used during the lectures and other teaching material will be available on AulaWeb at the end of each cycle of lessons together with other selected papers in pdf format.
The suggested books are available together with other books for further study at the teacher office.
Recommended texts for any further information:
Robbins e Cotran: Le basi patologiche delle malattie (ELSEVIER)
Rubin: Patologia (Casa Ed. Ambrosiana)
M. Pontieri: Patologia generale/ Fisiopatologia Generale – PICCIN
Ricevimento: Anytime by appointment
MARIAPAOLA NITTI (President)
ANNA MARIA BASSI
ANNA LISA FURFARO (President Substitute)
For lessons start and timetable go to the following link For lessons start and timetable go to the following link https://easyacademy.unige.it/portalestudenti/
MOLECULAR AND CELLULAR PATHOLOGY
The oral examination consists of the answer to questions asked by the teacher on topics covered during the course.
Three questions will be asked on the topics covered during the Course. To get a passing-grade for each question is mandatory to pass the exam. The final evaluation will take into account student ability to analyse in depht the topics, to use the specialistic vocabulary and to logically connect different aspects of molecular pathology.
Regular attendance at lectures is strongly recommended.
