CODE 80443 ACADEMIC YEAR 2020/2021 CREDITS 8 cfu anno 2 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/08 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2019/2020) GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2019 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Pharmaceutical chemistry and technology 8451 (coorte 2019/2020) INSTRUMENTAL ANALYSIS OF DRUGS (WITH PRACTICE) 80452 Pharmaceutical chemistry and technology 8451 (coorte 2019/2020) DRUGS ANALYSIS II 80445 TEACHING MATERIALS AULAWEB OVERVIEW The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative determination of substances of pharmaceutical interest, using classical and innovative methods. The topics of the theoretical course are conducted in close correlation with the practical trainings in laboratory. The frontal teaching can be also carried out remotely in telematic mode. AIMS AND CONTENT AIMS AND LEARNING OUTCOMES The course, divided into lectures and individual trainings in laboratory, aims to provide a basic understanding about the methods for the preparation and for the quantitative determination of compounds with medicinal use. TEACHING METHODS The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative dosage of substances of pharmaceutical interest, using classical and innovative methods. SYLLABUS/CONTENT Theoretical topics Guidelines on laboratory safety and chemical use Introduction to the quantitative determination of compounds registered in FU XII Ed. and FE VIII Ed. Overview of the analytical methods. Classification and selection of analitycal methods. Chemical analysis stages. Chemical, apparatus and methods for the quantitative determination of compounds with medicinal uses. Calculation used in pharmaceutical analysis. Sampling, standardization and calibration. Introduction to volumetric titrations in pharmaceutical analysis: chemical equilibria in volumetric analysis. Preparation of standard solutions. Techniques of preparing sample: filtration, extraction, distillation, chromatography Quantitative determination and applications: neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, potentiometry. Atomic absorption spectrometry (AAS) and applications. Practical trainings Extraction with solvent, distillation in vacuo. Chromatographyc separation and analysis of a mixture of drugs. Quantitative determination of drugs by mean of neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, potentiometry and AAS. RECOMMENDED READING/BIBLIOGRAPHY Fondamenti di chimica analitica di Skoog e West, Terza Edizione - F. James Holler e Stanley R. Crouch, EDISES – ISBN 9788879598651, on line dal 20 marzo 2015. Analisi chimico farmaceutica - F. Savelli, O. Bruno - PICCIN TEACHERS AND EXAM BOARD MICHELE TONELLI Ricevimento: From Monday to Friday, by appointment (via e-mail or telephone). Exam Board FRANCESCA MUSUMECI (President) MICHELE TONELLI (President) CHIARA BRULLO ELENA CICHERO PAOLA FOSSA LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral test. Exams can be also carried out remotely in telematic mode. ASSESSMENT METHODS The examination includes an oral test and an evaluation of the experimental ability achieved by the student while attending to practical trainings in laboratory Exam schedule Data appello Orario Luogo Degree type Note 08/04/2021 09:00 GENOVA Orale 22/06/2021 09:00 GENOVA Orale 06/07/2021 09:00 GENOVA Orale 20/07/2021 09:00 GENOVA Orale 16/09/2021 09:00 GENOVA Orale 24/01/2022 09:00 GENOVA Orale 15/02/2022 09:00 GENOVA Orale 15/02/2022 09:00 GENOVA Orale 15/02/2022 09:00 GENOVA Orale