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CODE 80443
ACADEMIC YEAR 2020/2021
CREDITS
SCIENTIFIC DISCIPLINARY SECTOR CHIM/08
LANGUAGE Italian
TEACHING LOCATION
  • GENOVA
SEMESTER 1° Semester
PREREQUISITES
Propedeuticità in ingresso
Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami:
  • Pharmaceutical chemistry and technology 8451 (coorte 2019/2020)
  • GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2019
Propedeuticità in uscita
Questo insegnamento è propedeutico per gli insegnamenti:
  • Pharmaceutical chemistry and technology 8451 (coorte 2019/2020)
  • INSTRUMENTAL ANALYSIS OF DRUGS (WITH PRACTICE) 80452
  • Pharmaceutical chemistry and technology 8451 (coorte 2019/2020)
  • DRUGS ANALYSIS II 80445
TEACHING MATERIALS AULAWEB

OVERVIEW

The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative determination of substances of pharmaceutical interest, using classical and innovative methods. The topics of the theoretical course are conducted in close correlation with the practical trainings in laboratory. The frontal teaching can be also carried out remotely in telematic mode.

AIMS AND CONTENT

AIMS AND LEARNING OUTCOMES

The course, divided into lectures and individual trainings in laboratory, aims to provide a basic understanding about the methods for the preparation and for the quantitative determination of compounds with medicinal use.

TEACHING METHODS

The course is developed with a theoretical (40 hrs) and practical lessons (54 hrs for each student) concerning the pre-treatment and the quantitative dosage of substances of pharmaceutical interest, using classical and innovative methods. 

SYLLABUS/CONTENT

Theoretical topics

Guidelines on laboratory safety and chemical use

Introduction to the quantitative determination of compounds registered in FU XII Ed. and FE VIII Ed.

Overview of the analytical methods. Classification and selection of analitycal methods. Chemical analysis stages. Chemical, apparatus and methods for the quantitative determination of compounds with medicinal uses. Calculation used in pharmaceutical analysis. Sampling, standardization and calibration.

Introduction to volumetric titrations in pharmaceutical analysis: chemical equilibria in volumetric analysis. Preparation of standard solutions.

Techniques of preparing sample: filtration, extraction, distillation, chromatography

Quantitative determination and applications: neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, potentiometry.

Atomic absorption spectrometry (AAS) and applications.

Practical trainings

Extraction with solvent, distillation in vacuo. Chromatographyc separation and analysis of a mixture of drugs. Quantitative determination of drugs by mean of neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, potentiometry and AAS.

RECOMMENDED READING/BIBLIOGRAPHY

  • Fondamenti di chimica analitica di Skoog e West, Terza Edizione - F. James Holler e Stanley R. Crouch, EDISES – ISBN 9788879598651, on line dal 20 marzo 2015.
  • Analisi chimico farmaceutica - F. Savelli, O. Bruno - PICCIN

TEACHERS AND EXAM BOARD

Exam Board

FRANCESCA MUSUMECI (President)

MICHELE TONELLI (President)

CHIARA BRULLO

ELENA CICHERO

PAOLA FOSSA

LESSONS

Class schedule

The timetable for this course is available here: Portale EasyAcademy

EXAMS

EXAM DESCRIPTION

Oral test. Exams can be also carried out remotely in telematic mode.

ASSESSMENT METHODS

The examination includes an oral test and an evaluation of the experimental ability achieved by the student while attending to practical trainings in laboratory

Exam schedule

Data appello Orario Luogo Degree type Note
08/04/2021 09:00 GENOVA Orale
22/06/2021 09:00 GENOVA Orale
06/07/2021 09:00 GENOVA Orale
20/07/2021 09:00 GENOVA Orale
16/09/2021 09:00 GENOVA Orale
24/01/2022 09:00 GENOVA Orale
15/02/2022 09:00 GENOVA Orale
15/02/2022 09:00 GENOVA Orale
15/02/2022 09:00 GENOVA Orale