AIMS AND CONTENT

LEARNING OUTCOMES

The course aims to provide knowledge on the fundamental and technological aspects related to tissue engineering, with particular reference to cell biology, stem cells, biocompatibility, biotechnological approach and gene therapy, regenerative medicine.

AIMS AND LEARNING OUTCOMES

The teaching is intended to provide theoretical and practical tools for understanding and solving problems in the field of tissue engineering. The main aim is underline the importance of understanding biological phenomena at the molecular, cellular and tissue level in order to develop therapeutic strategies that can overcome the limits of conventional therapies. The applicative examples, that will be proposed, will thus have the purpose of stimulating and developing the student's abilities in applying theoretical knowledge to the field of tissue engineering.

TEACHING METHODS

Combination of traditional lectures (40 hours) and laboratory (8 hours). 

SYLLABUS/CONTENT

•    Chemical Bioengineering: biomolecules, structure-function relationship, biomolecules in bioengineering applications.
•    Fundamentals of biotechnology: recombinant DNA and genetic techniques.
•    Fundamentals of cytology: structure and function of the eukaryotic cell, the extracellular matrix, cell adhesion mechanisms.
•    Maintenance and expansion of in vitro cell cultures. Primary cells, immortalized cells and stem cells.
•    Definition of biological tissue and of its organization.
•    Biomaterials for regenerative medicine: hydrogels.
•    Techniques for the evaluation of biocompatibility: in vitro, in vivo and clinical trials. Methodologies for the modification of the surface properties of biomaterials. Bioreactors.
•    Micro and nano systems for the controlled release of drugs and biomolecules.

RECOMMENDED READING/BIBLIOGRAPHY

Teaching material available on Aulaweb.

TEACHERS AND EXAM BOARD

Exam Board

LAURA PASTORINO (President)

ELENA DELLACASA

DONATELLA DI LISA

MAURO GIACOMINI (President Substitute)

LESSONS

Class schedule

The timetable for this course is available here: Portale EasyAcademy

EXAMS

EXAM DESCRIPTION

Oral exam

ASSESSMENT METHODS

At the end of the teaching the student must demonstrate to:

• Have understood the fundamental aspects of molecular, cellular and tissue engineering.
• Being able to discuss to correlate the diffrent  teaching topics.
• Discuss the presented technologies starting  from their physiological bases.

Exam schedule