CODE 34001 ACADEMIC YEAR 2021/2022 CREDITS 4 cfu anno 3 CHIMICA E TECNOLOGIE CHIMICHE 8757 (L-27) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/06 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Chemistry and Chemical Technologies 8757 (coorte 2019/2020) LABORATORY OF ORGANIC CHEMISTRY 65111 2019 ORGANIC CHEMISTRY 2 65113 2019 MATHEMATICAL INSTITUTIONS 72564 2019 TEACHING MATERIALS AULAWEB AIMS AND CONTENT LEARNING OUTCOMES To give a general idea of various aspects where organic chemistry is connected with biology. In particular: structure functioning of proteins (enzymes, receptors, channels) and oligosaccharides, and their interaction with potential drugs. TEACHING METHODS Traditional lessons in the classroom (32 hours). The attendance is not compulsory but, for statistical means, it wil be anyway monitored. SYLLABUS/CONTENT Protein: secondary, tertiary and quaternary structure Enzymes: kynetics, catalysis mechanism, examples, classification . Principle of drug discovery. Enzyme inhibitors, receptors, ion channels. Glycochemistry. Applications in the fields of antiviral, antitumor drugs, antibiotics, antiinflammatory drugs, anti-asthma drugs, drugs for cardiovascular diseases and so on. RECOMMENDED READING/BIBLIOGRAPHY Silverman, R.B., "The Organic Chemistry of Drug Design and Drug Action", Academic Press Corey, E.J., Czakó, B. Kürti, L., "Molecules and Medicines", Wiley TEACHERS AND EXAM BOARD LUCA BANFI Ricevimento: The teacher is always present in the Department between 8.00 and 13.00 and 15.00 and 18.30 (except in august). The students can come to speak with him in any moment, unless he is engaged in other isntitutional activities. However, it is highly advised to arrange an appointment by E-mail, in order to be sure to find him free. Exam Board LUCA BANFI (President) RENATA RIVA LISA MONI (President Substitute) CHIARA LAMBRUSCHINI (Substitute) LESSONS LESSONS START 2 march 2020 (timetable on http://www.chimica.unige.it/didattica/orari_CTC or https://corsi.unige.it/8757) Class schedule BIOORGANIC CHEMISTRY EXAMS EXAM DESCRIPTION The exam will be oral. Only the subjects treated during the lessons (as reported in the slides deposited in aulaweb) will be object of the exam. Students must register to the exam at least 48 hours in advance on https://servizionline.unige.it/studenti/esami/prenotazione ASSESSMENT METHODS The oral exam is always carried out by two teachers with at least 5 years of experience and will last at least 30 minutes. In this way, the commission is definitely able to verify with high accuracy if the student has reached or not the learning outcomes. During the oral exam the student must demonstrate to have reached the learning outcomes, both orally and (most importantly) writing formulas, chemical equations, mechanisms. When the commission will judge that the learning oucomes have not been reached, the students will be invited to repeat the exam in one of the subsequent dates. Exam schedule Data appello Orario Luogo Degree type Note 26/01/2022 15:00 GENOVA Orale 23/02/2022 15:00 GENOVA Orale 25/05/2022 15:00 GENOVA Orale 29/06/2022 15:00 GENOVA Orale 20/07/2022 15:00 GENOVA Orale 14/09/2022 15:00 GENOVA Orale 05/10/2022 15:00 GENOVA Orale 25/01/2023 15:00 GENOVA Orale 22/02/2023 15:00 GENOVA Orale
