CODE 64200 ACADEMIC YEAR 2021/2022 CREDITS 8 cfu anno 3 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/14 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2019/2020) GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2019 MATHEMATICS (PCT)(MD) 55402 2019 PHYSICS (PCT)(MD) 55404 2019 ORGANIC CHEMISTRY I (PCT)(MD) 60822 2019 ORGANIC CHEMISTRY II (PCT)(MD) 60828 2019 GENERAL PHYSIOLOGY (PCT)MD) 60829 2019 ANIMAL BIOLOGY AND HUMAN ANATOMY (I.C.)(PCT MD) 64555 2019 BIOCHEMISTRY AND APPLIED BIOCHEMISTRY (I.C.)(PCT MD) 80520 2019 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Pharmaceutical chemistry and technology 8451 (coorte 2019/2020) PHARMACOLOGY AND PHARMACOTHERAPY (PCT) 67563 TEACHING MATERIALS AULAWEB OVERVIEW The course is aimed at providing the bases of pharmacology and toxicology. Moreover, will be provided knowledge and tools related to scientific research in this field. AIMS AND CONTENT LEARNING OUTCOMES The course of Pharmacology aims to provide knowledge about the general mechanisms of drug interactions with the biological structures. The course will deal from a qualitative and quantitative point of view: the interactions of drugs with receptors and other proteins the mechanisms of drug absorption, distribution, metabolism, and elimination. the individual variability of the drug response the toxicity of a drug the mechanisms of drug interactions AIMS AND LEARNING OUTCOMES The goal is to create a reliable basis to deal with drug management. The learning outcomes will be based on the evaluation of three fundamental aspects: appropriateness of terminology skills and notions reasoning ability TEACHING METHODS Frontal lectures or, if necessary, in telematic teaching mode. SYLLABUS/CONTENT 1. General Pharmacology and Toxicology 2. Pharmacodynamics 3. Pharmacokinetics (PK) 4. Challenges in Pharmacological Research 5. Receptors 6. Ionotropic Rs (IRs) 7. Metabotropic R Metabotropy (MRs) 8. IRs Main families, localization, activities 9. MRs Main families, localization, activities 10. Other receptors 11. Carrier (T) 12. T Main families, localization, activities 13. Non-functional Techniques 14. Functional Techniques 15. Drug-Receptor interaction (FR) 16. Pharmacological Theories 17. FR Constants and parameters 18. FR Linear and logarithmic graphic representations 19. Computer software and tools 20. Allosteric and orthosteric ligands 21. Absorption 22. Distribution 23. Metabolism 24. Elimination 25. PK In the elderly 26. PK In the smoker 27. PK In the cannabis consumer 28. PK in the obesity 29. Routes of administration 30. Ways of elimination 31. Metabolism's Phases, genetic variations and processes 32. PK Parameters and kinetics 33. Toxicology 34. Drugs Handling 35. Preclinical, and clinical trials 36. Toxicity test 37. Mechanisms of Toxicity 38. ADR and Pharmacovigilance 39. Forensic toxicology 40. Contrast liquids RECOMMENDED READING/BIBLIOGRAPHY Goodman & Gilman Le basi farmacologiche della terapia Zanichelli Hitner & Nagle Principi di Farmacologia Zanichelli Katzung, Master, Trevor Frmacologia Generale e clinica Piccin Casarett & Doull Elementi di tossicologia Casa editrice Ambrosiana Tossicologia generale e applicata ai farmaci- Manzo, Paolillo e Vitalone -edra Il meccanismo d'azione dei farmaci Francesco Clementi Guido Fumagalli-edra TEACHERS AND EXAM BOARD MASSIMO GRILLI Ricevimento: on appointment Exam Board MASSIMO GRILLI (President) CHIARA CERVETTO ERNESTO FEDELE MANLIO MILANESE GUENDALINA OLIVERO ANNA MARIA PITTALUGA LUCA RAITERI LESSONS LESSONS START Starting date: March 01, 2021 MS Teams Code: c763qws Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral exams (frontal or telematic mode). Exam schedule Data appello Orario Luogo Degree type Note 15/04/2022 10:00 GENOVA Orale 22/06/2022 10:00 GENOVA Orale 06/07/2022 10:00 GENOVA Orale 20/07/2022 10:00 GENOVA Orale 16/09/2022 10:00 GENOVA Orale 23/12/2022 14:00 GENOVA Orale 25/01/2023 10:00 GENOVA Orale 22/02/2023 10:00 GENOVA Orale