Acquire knowledge about the main toxicological actions caused by acute or chronic exposure of some classes of xenobiotics. Acquire the basic notions of drug / toxic-kinetics. In particular, knowledge will be required: of the mechanisms that regulate the absorption of drugs and toxic substances, with particular regard to the pathways of absorption / intoxication; their distribution, metabolism and elimination. Know the main aspects of pharmacodynamics in particular the mechanisms of action with which drugs and xenobiotics act. Know the organ-specific toxicity of various compounds. Know the possible pharmacological treatments in case of acute or chronic poisoning by pesticides, some heavy metals and gases and vapors.
Frontal lessons
Drug/toxic-kinetic overview: Absorption - Distribution - Metabolism - Elimination
Outline of drug-toxic-dynamics - DL50 - Safety data sheets
Organ-specific toxicity
Toxicity of the main heavy metals
Toxicity of the main pesticides
Toxicity of gases, vapors and solvents
The didactic material used during the lessons will be made available to students
Recommended supplementary text: “Elementi di tossicologia” Casarett & Doul Casa Editrice Ambrosiana
Ricevimento: By appointament e-mail luigi.robbiano@unige.it
FRANCESCO D'AGOSTINI (President)
ANDREA DE MARIA (President)
BARBARA MARENGO
LUIGI ROBBIANO
VINCENZO TROVATO
CINZIA MARIA DOMENICOTTI (President and Coordinator of Integrated Course)
As per the didactic calendar
The exam takes place in oral form.
The verification of the correct understanding of the topics covered takes place during the exam with questions aimed at verifying the ability to actively apply the knowledge acquired during the course through reasoning and synthesis.
