The course is transformed by combining with the molecular biology module. The interest for biotechnological drugs will be characterized by in-depth studies and dedicated lessons.
The course is aimed at providing the bases of pharmacology and toxicology. Moreover, will be provided knowledge and tools related to scientific research in this field.
The course of Pharmacology aims to provide knowledge about the general mechanisms of drug interactions with the biological structures. The course will deal from a qualitative and quantitative point of view:
The goal is to create a solid foundation for dealing with the management of the drug.
The student will learn what a pharmacological problem means, analyze the efficacy and safety of a drug and evaluate specific cases related to the emerging development of biotechnological drugs
General chemistry and inorganic
Organic chemical I.
Organic chemical II.
Biochemistry and applied biochemistry
Animal biology and human anatomy
Maths
Physics
General Physiology
Frontal lectures or, if necessary, in telematic teaching mode.
Any Student with documented Specific Learning Disorders (SLD), or with any special needs, shall reach out to the Lecturer(s) and to the dedicated SLD Representative in the Department ( Prof. Luca Raiteri, Luca.Raiteri@unige.it ) before class begins, in order to liaise and arrange the specific learning methods and ensure proper achievement of the learning aims and outcomes. VERY IMPORTANT: any request for compensatory tools and adaptations in the exam MUST be done within 10 working days before the date of the exam according to the instructions that can be found at https://unige.it/disabilita-dsa/comunicazioni
1. General Pharmacology and Toxicology 2. Pharmacodynamics 3. Pharmacokinetics (PK) 4. Challenges in Pharmacological Research 5. Receptors 6. Ionotropic Rs (IRs) 7. Metabotropic R Metabotropy (MRs) 8. IRs Main families, localization, activities 9. MRs Main families, localization, activities 10. Other receptors 11. Carrier (T) 12. T Main families, localization, activities 13. Non-functional Techniques 14. Functional Techniques 15. Drug-Receptor interaction (FR) 16. Pharmacological Theories 17. FR Constants and parameters 18. FR Linear and logarithmic graphic representations
19. Computer software and tools 20. Allosteric and orthosteric ligands 21. Absorption 22. Distribution 23. Metabolism 24. Elimination 25. PK In the elderly 26. PK In the smoker 27. PK In the cannabis consumer 28. PK in the obesity 29. Routes of administration 30. Ways of elimination 31. Metabolism's Phases, genetic variations and processes 32. PK Parameters and kinetics 33. Toxicology 34. Drugs Handling 35. Preclinical, and clinical trials 36. Toxicity test 37. Mechanisms of Toxicity
38. ADR and Pharmacovigilance 39. Forensic toxicology 40. Contrast liquids
41 Vaccines and biotechnological drugs
Goodman & Gilman Le basi farmacologiche della terapia Zanichelli
Hitner & Nagle Principi di Farmacologia Zanichelli
Katzung, Master, Trevor Frmacologia Generale e clinica Piccin
Casarett & Doull Elementi di tossicologia Casa editrice Ambrosiana
Tossicologia generale e applicata ai farmaci- Manzo, Paolillo e Vitalone -edra
Il meccanismo d'azione dei farmaci Francesco Clementi Guido Fumagalli-edra
Rossi, Cuomo, Riccardi Farmacologia principi di base e applicazioni terapeutiche V ed Edizioni Minerva Medica
Oral examination
The learning outcomes will be based on the assessment during the examination of three key aspects:
appropriateness of the terminology skills and notions reasoning ability
