Cellular and Molecular Pathology (6 CFU) is a mandatory exam in the 2nd year of the MHB course (sping period)
This course aims at providing deep knowledge of the molecular mechanisms underlying the most important human diseases. The alterations of structures, functions and control mechanisms in degenerative pathologies as well as in neoplastic transformations will be studied at molecular, cellular and tissue level. Students will be able to use and apply this knowledge both in research activity and in clinical laboratory
The deep knowledge of molecular mechanisms underlying the loss of homeostatic ability in tissues and the pathogenesis of the main human pathologies is fundamental for the students and will be crucial in stutent's research activity and in clinical laboratory activity as well.
In-depht knowledge in biochemistry, human anatomy and physiology is fundamental to approach the course.
48 hours of lectures and seminars
Cell adaptations: modifications of cell growth and differentiation. Atrophy, hypoplasia, hypertrophy, metaplasia.
Cell injury: hypoxic/ischemic damage, chemical damage, free radical damage.
Cellular responses to stress: alteration of lysosoms, mitochondria, endoplasmic reticulum, cytoskeleton.
Cell death: necrosis/apoptosis
Cell and tissue degenerations: primary dysfunctions/intracellular accumulations/extracellular accumulations/pathological pigmentations.
Liver pathologies: Steatosis, Fibrosis, Cirrhosis
Hemosiderosis, Wilson Disease.
Amyloidosis
Atherosclerosis: pathogenesis and sequelae
Hemostasis and thrombosis
Bleeding diathesis: congenital and acquider disorders. CID
Vascular pathologies: edema, embolism, thrombosis, infarction, shock
Anemias (congenital and acquired), leucopoenia, leukocytosis, leukaemia
Diabetes: pathogenesis and sequelae
Nervous system pathologies: epilepsy, multiple sclerosis, tetanus (overview)
Parkinson Disease and Alzheimer Disease: histological features and pathogenetic mechanisms
Neoplasia:
Tumor atypias. Metastasis
Benign tumors and cancers. histological classification. TNM system
Molecular mechanisms of carcinogenesis. Oncogenes and tumor suppressor genes
Carcinogenic compounds, radiations, biological agents
Immune system and cancer (overview)
Angiogenesis and cancer (overview)
Robbins e Cotran: Le basi patologiche delle malattie (ELSEVIER)
Rubin: Patologia (Casa Ed. Ambrosiana)
M. Pontieri: Patologia generale/ Fisiopatologia Generale – PICCIN
Teaching materials for students available at AulaWeb
Ricevimento: Anytime by appointment
MARIAPAOLA NITTI (President)
ANNA MARIA BASSI
CARLO PENCO
February/March 2019
Oral examination
Three questions will be asked on the topics covered during the Course. To get a passing-grade for each question is mandatory to pass the exam. The final evaluation will take into account student ability to analyse in depht the topics, to use the specialistic vocabulary and to logically connect different aspects of molecular pathology.
