OVERVIEW

Epigenomic and genomic mechanisms related with diseases. Polymorphisms in DNA sequence and its effects. Dominant and recessive inherited diseases. Epigenetic mechanisms of regulation of gene expression and its effects on the phenotype

AIMS AND CONTENT

LEARNING OUTCOMES

Epigenomic and genomic mechanisms related with diseases. Polymorphisms in DNA sequence and its effects. Dominant and recessive inherited diseases. Epigenetic mechanisms of regulation of gene expression and its effects on the phenotype

TEACHING METHODS

Most of the classes are magistral classes in which the students discuss the different themes with the professor. The students expose a seminar of a selected article which is further discussed by the class

SYLLABUS/CONTENT

1. Genome and epigenome.

1.1. Polymorphisms and their effects on the phenotype. Dominant and recessive inheritance.
1.2. Epigenetic mechanisms and their effects on gene expression

2. Genetic diseases.

2.1. Monogenetic diseases.
2.2. Genetic predisposition and multifactorial diseases

3. Epigenetic diseases.

2.1. Hereditary diseases.
2.2. Genetic predisposition and multifactorial diseases.
2.3. Epigenetics and cancer.

RECOMMENDED READING/BIBLIOGRAPHY

• Pierce, Benjamin A. Genetics, a conceptual approach (5th ed.). Ed McMillan
• C. David Allis (Editor), Marie-Laure Caparros, Thomas Jenuwein,Danny Reinberg Epigenetics (2015) Cold Spring Harbor Laboratory Press 

Brown, T. A. Genomes 3rd ed. (2006) Garland Science

LESSONS

FURTHER INFORMATION

Frequency

Optional course