CODE 91092 ACADEMIC YEAR 2018/2019 CREDITS 6 cfu anno 2 BIOLOGIA MOLECOLARE E SANITARIA 9015 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/14 LANGUAGE English TEACHING LOCATION GENOVA SEMESTER 2° Semester TEACHING MATERIALS AULAWEB OVERVIEW Providing in-depth knowledge on main classes of drugs and on their use as a therapeutic tools, on cellular and molecular mechanisms of the drug action, and on the pharmacological modulation of cell responses. in-depth knowledge of pharmacodynamics, pharmacokinetics and adverse drug reaction and toxicity of the main drug classes. Therapeutic perspectives and rationals to design new drugs for selective intervention on cellular and molecular mechanisms AIMS AND CONTENT LEARNING OUTCOMES Providing in-depth knowledge on main classes of drugs and on their use as a therapeutic tools, on cellular and molecular mechanisms of the drug action, and on the pharmacological modulation of cell responses. in-depth knowledge of pharmacodynamics, pharmacokinetics and adverse drug reaction and toxicity of the main drug classes. Therapeutic perspectives and rationals to design new drugs for selective intervention on cellular and molecular mechanisms TEACHING METHODS The course consists of a total of 48 hours of lessons. SYLLABUS/CONTENT Introductory remarks on intercellular communication in the nervous system: the neurotransmission; regulation of neurotransmission. The vesicular exocytotic cycle and toxins CHOLINERGIC SYSTEM – ADRENERGIC SYSTEM Synthesis and catabolism of neurotransmitters; cholinergic and noradrenergic transmission in central nervous system and autonomic nervous system DRUGS OF THE AUTONOMIC NERVOUS SYSTEM Cholinomimetic drugs and anticholinergic drugs: mechanisms of action and effects, side effects, therapeutic uses Sympathomimetic and alpha and beta-adrenergic receptor antagonists: mechanisms of action and effects, side effects, therapeutic uses Ganglioplegic drugs: mechanisms of action and effects, adverse drug reaction, therapeutic uses Neuromuscular-blocking drugs: mechanisms of action and effects, side effects, therapeutic uses DRUGS OF THE DOPAMINERGIC SYSTEM Introductory remarks on dopaminergic neurotransmission Antiparkinson agents: mechanisms of action and effects, side effects, therapeutic uses Antipsychotic drugs: mechanisms of action and effects, side effects, therapeutic uses SEROTONERGIC DRUGS Introductory remarks on serotonergic neurotransmission Antidepressants: mechanisms of action and effects, side effects, therapeutic uses Introductory remarks on therapy of migraine DRUGS OF THE GABAERGIC SYSTEM Introductory remarks on GABAergic neurotransmission Anxyolitics: mechanisms of action and effects, side effects, therapeutic uses Antiepileptic drugs: mechanisms of action and effects, side effects, therapeutic uses THE GLUTAMATERGIC SYSTEM Introductory remarks on glutamatergic neurotransmission Ionotropic and metabotropic receptors for glutamate Excitotoxicity. Mechanisms of excitotoxicity; Introductory remarks on neurodegenerative disease and excitotoxic mechanisms ANTIARRHYTHMIC DRUGS · : mechanisms of action and effects, side effects, therapeutic uses. New targets for antiarrhythmic drugs; research and development of new drugs INOTROPIC AGENTS. Cardiac glycosides: mechanisms of action and effects, side effects, therapeutic uses. New targets for inotropic agents; research and development of new drugs DRUGS FOR ISCHEMIC HEART DISEASE. Introductory remarks on pathophysiology of coronary blood flow dysfunction and ischemic cardiopathy; potential targets for pharmacological intervention. Drug for chest pain: mechanisms of action and effects, side effects, therapeutic uses. DIURETICS. Mechanisms of action and effects, side effects, therapeutic uses. New targets for diuretic agents; research and development of new drugs ANTIHYPERTENSIVE DRUGS. Vascular tone and antihypertensive drugs. Contraction of the smooth muscle cells: control of muscular tone and pharmacological modulation of vascular tone. Vascular smooth muscle and control of the vascular tone; vasodilators ANTIASTHMATIC DRUGS. Bronchial smooth muscle. bronchodilators and antiasthmatic drugs: mechanisms of action and effects, side effects, therapeutic uses. New targets for diuretic agents; research and development of new drugs. RECOMMENDED READING/BIBLIOGRAPHY Author: Golan DE et al Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy Third Edition Lippincott Williams & Wilkins, 2012 Author: Brunton LL et al Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th Edition McGraw Hill, 2011 LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy
