CODE 91091 ACADEMIC YEAR 2018/2019 CREDITS 6 cfu anno 2 BIOLOGIA MOLECOLARE E SANITARIA 9015 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE English TEACHING LOCATION GENOVA SEMESTER 2° Semester TEACHING MATERIALS AULAWEB OVERVIEW Molecular Pathology 6 credits (CFU) in the spring period, is a mandatory exam in the 2nd year of the MHB course. AIMS AND CONTENT LEARNING OUTCOMES This course aims at providing deep knowledge of the molecular mechanisms underlying the most important human diseases. The alterations of structures, functions and control mechanisms in degenerative pathologies as well as in neoplastic transformations will be studied at molecular, cellular and tissue level. Students will be able to use and apply this knowledge both in research activity and in clinical laboratory AIMS AND LEARNING OUTCOMES The deep knowledge of molecular mechanisms underlying the loss of homeostatic ability in tissues and the pathogenesis of the main human pathologies is fundamental for the students and will be crucial in stutent's research activity and in clinical laboratory activity as well. PREREQUISITES In-depht knowledge in biochemistry, human anatomy and physiology is fundamental to approach the course. TEACHING METHODS 48 hours of lectures and seminars SYLLABUS/CONTENT Cell adaptations: modifications of cell growth and differentiation. Atrophy, hypoplasia, hypertrophy, metaplasia. Cell injury: hypoxic/ischemic damage, chemical damage, free radical damage. Cellular responses to stress: alteration of lysosoms, mitochondria, endoplasmic reticulum, cytoskeleton. Cell death: necrosis/apoptosis Cell and tissue degenerations: primary dysfunctions/intracellular accumulations/extracellular accumulations/pathological pigmentations. Liver pathologies: Steatosis, Fibrosis, Cirrhosis Hemosiderosis, Wilson Disease. Amyloidosis Atherosclerosis: pathogenesis and sequelae Hemostasis and thrombosis Bleeding diathesis: congenital and acquider disorders. CID Vascular pathologies: edema, embolism, thrombosis, infarction, shock Anemias (congenital and acquired), leucopoenia, leukocytosis, leukaemia Diabetes: pathogenesis and sequelae Nervous system pathologies: epilepsy, multiple sclerosis, tetanus (overview) Parkinson Disease and Alzheimer Disease: histological features and pathogenetic mechanisms Neoplasia: Tumor atypias. Metastasis Benign tumors and cancers. histological classification. TNM system Molecular mechanisms of carcinogenesis. Oncogenes and tumor suppressor genes Carcinogenic compounds, radiations, biological agents Immune system and cancer (overview) Angiogenesis and cancer (overview) RECOMMENDED READING/BIBLIOGRAPHY Robbins e Cotran: Le basi patologiche delle malattie (ELSEVIER) Rubin: Patologia (Casa Ed. Ambrosiana) M. Pontieri: Patologia generale/ Fisiopatologia Generale – PICCIN Teaching materials for students available at AulaWeb TEACHERS AND EXAM BOARD MARIAPAOLA NITTI Ricevimento: Anytime by appointment Exam Board MARIAPAOLA NITTI (President) LESSONS LESSONS START February/March 2019 Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral examination ASSESSMENT METHODS Three questions will be asked on the topics covered during the Course. To get a passing-grade for each question is mandatory to pass the exam. The final evaluation will take into account student ability to analyse in depht the topics, to use the specialistic vocabulary and to logically connect different aspects of molecular pathology. Exam schedule Data appello Orario Luogo Degree type Note 25/01/2019 10:00 GENOVA Orale 15/02/2019 10:00 GENOVA Orale 21/06/2019 10:00 GENOVA Orale 05/07/2019 10:00 GENOVA Orale 19/07/2019 10:00 GENOVA Orale 09/09/2019 10:00 GENOVA Orale 19/09/2019 15:00 GENOVA Orale