CODE 91093 ACADEMIC YEAR 2018/2019 CREDITS 3 cfu anno 2 BIOLOGIA MOLECOLARE E SANITARIA 9015 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/03 LANGUAGE English TEACHING LOCATION GENOVA SEMESTER 1° Semester MODULES Questo insegnamento è un modulo di: PATHOLOGY OF INHERITANCE AND MICROBIOLOGY TEACHING MATERIALS AULAWEB OVERVIEW Epigenomic and genomic mechanisms related with diseases. Polymorphisms in DNA sequence and its effects. Dominant and recessive inherited diseases. Epigenetic mechanisms of regulation of gene expression and its effects on the phenotype AIMS AND CONTENT LEARNING OUTCOMES Epigenomic and genomic mechanisms related with diseases. Polymorphisms in DNA sequence and its effects. Dominant and recessive inherited diseases. Epigenetic mechanisms of regulation of gene expression and its effects on the phenotype TEACHING METHODS Most of the classes are magistral classes in which the students discuss the different themes with the professor. The students expose a seminar of a selected article which is further discussed by the class SYLLABUS/CONTENT 1. Genome and epigenome. 1.1. Polymorphisms and their effects on the phenotype. Dominant and recessive inheritance. 1.2. Epigenetic mechanisms and their effects on gene expression 2. Genetic diseases. 2.1. Monogenetic diseases. 2.2. Genetic predisposition and multifactorial diseases 3. Epigenetic diseases. 2.1. Hereditary diseases. 2.2. Genetic predisposition and multifactorial diseases. 2.3. Epigenetics and cancer. RECOMMENDED READING/BIBLIOGRAPHY Pierce, Benjamin A. Genetics, a conceptual approach (5th ed.). Ed McMillan C. David Allis (Editor), Marie-Laure Caparros, Thomas Jenuwein,Danny Reinberg Epigenetics (2015) Cold Spring Harbor Laboratory Press Brown, T. A. Genomes 3rd ed. (2006) Garland Science LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy FURTHER INFORMATION Frequency Optional course
