Providing in-depth knowledge on main classes of drugs and on their use as a therapeutic tools, on cellular and molecular mechanisms of the drug action, and on the pharmacological modulation of cell responses. in-depth knowledge of pharmacodynamics, pharmacokinetics and adverse drug reaction and toxicity of the main drug classes. Therapeutic perspectives and rationals to design new drugs for selective intervention on cellular and molecular mechanisms
The course consists of a total of 48 hours of lessons.
Introductory remarks on intercellular communication in the nervous system: the neurotransmission; regulation of neurotransmission. The vesicular exocytotic cycle and toxins
CHOLINERGIC SYSTEM – ADRENERGIC SYSTEM
Synthesis and catabolism of neurotransmitters; cholinergic and noradrenergic transmission in central nervous system and autonomic nervous system
DRUGS OF THE AUTONOMIC NERVOUS SYSTEM
Cholinomimetic drugs and anticholinergic drugs: mechanisms of action and effects, side effects, therapeutic uses
Sympathomimetic and alpha and beta-adrenergic receptor antagonists: mechanisms of action and effects, side effects, therapeutic uses
Ganglioplegic drugs: mechanisms of action and effects, adverse drug reaction, therapeutic uses
Neuromuscular-blocking drugs: mechanisms of action and effects, side effects, therapeutic uses
DRUGS OF THE DOPAMINERGIC SYSTEM Introductory remarks on dopaminergic neurotransmission
Antiparkinson agents: mechanisms of action and effects, side effects, therapeutic uses
Antipsychotic drugs: mechanisms of action and effects, side effects, therapeutic uses
SEROTONERGIC DRUGS Introductory remarks on serotonergic neurotransmission
Antidepressants: mechanisms of action and effects, side effects, therapeutic uses
Introductory remarks on therapy of migraine
DRUGS OF THE GABAERGIC SYSTEM Introductory remarks on GABAergic neurotransmission
Anxyolitics: mechanisms of action and effects, side effects, therapeutic uses
Antiepileptic drugs: mechanisms of action and effects, side effects, therapeutic uses
THE GLUTAMATERGIC SYSTEM Introductory remarks on glutamatergic neurotransmission
Ionotropic and metabotropic receptors for glutamate
Excitotoxicity. Mechanisms of excitotoxicity; Introductory remarks on neurodegenerative disease and excitotoxic mechanisms
ANTIARRHYTHMIC DRUGS · : mechanisms of action and effects, side effects, therapeutic uses. New targets for antiarrhythmic drugs; research and development of new drugs
INOTROPIC AGENTS. Cardiac glycosides: mechanisms of action and effects, side effects, therapeutic uses. New targets for inotropic agents; research and development of new drugs
DRUGS FOR ISCHEMIC HEART DISEASE. Introductory remarks on pathophysiology of coronary blood flow dysfunction and ischemic cardiopathy; potential targets for pharmacological intervention.
Drug for chest pain: mechanisms of action and effects, side effects, therapeutic uses.
DIURETICS. Mechanisms of action and effects, side effects, therapeutic uses. New targets for diuretic agents; research and development of new drugs
ANTIHYPERTENSIVE DRUGS. Vascular tone and antihypertensive drugs. Contraction of the smooth muscle cells: control of muscular tone and pharmacological modulation of vascular tone.
Vascular smooth muscle and control of the vascular tone; vasodilators
ANTIASTHMATIC DRUGS. Bronchial smooth muscle. bronchodilators and antiasthmatic drugs: mechanisms of action and effects, side effects, therapeutic uses. New targets for diuretic agents; research and development of new drugs.
Author: Golan DE et al
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy
Third Edition
Lippincott Williams & Wilkins, 2012
Author: Brunton LL et al
Goodman & Gilman's The Pharmacological Basis of Therapeutics
12th Edition
McGraw Hill, 2011
