CODE 66712 ACADEMIC YEAR 2018/2019 CREDITS 3 cfu anno 2 MONITORAGGIO BIOLOGICO 9016 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/14 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester OVERVIEW The Toxicology is the science that studies the toxic effects of xenobiotics, physical agents and biological organisms and in particular the mechanistic and descriptive aspects of the effects deriving from the interaction between toxic agents and living organism. The Toxicology is an integral part of the pharmacology, but applies not only to drugs but also to chemicals and has its applications in general and legal medicine, in occupational medicine and in food hygiene. AIMS AND CONTENT LEARNING OUTCOMES The course provides update knowledge on toxicokinetic and toxicodynamic of an exogenous compound within an organism; mechanisms of toxicity: functional toxicity, cytotoxicity, genotoxicity, teratology and foetal toxicity; side and toxic effects of drugs, the toxicity of xenobiotics; toxicity at the level of tissues and organs. AIMS AND LEARNING OUTCOMES The aim of the course is to provide updated knowledge on toxicokinetic and toxicodynamic of an exogenous compound within an organism; mechanisms of toxicity: functional toxicity, cytotoxicity, genotoxicity, teratology and fetal toxicity; side and toxic effects of drugs, the toxicity of xenobiotics; toxicity at the level of tissues and organs. At the end of the learning process the student will be able to develop critical thinking describing the quality- and quantitative toxicological effects of xenobiotics and to apply the acquired knowledge also to other molecules. TEACHING METHODS The teaching methods used will be the carrying out of lectures with in-depth analysis of the program. Therefore, the frequency of lessons is recommended. SYLLABUS/CONTENT Essential lexicon in Pharmacology and Toxicology: active substances (drugs; medicinal preparations; medicinal herbs; placebo), xenobiotics, toxicological agent. The scope of the field. Acute and chronic toxicological studies. Therapeutic Index and Margin of Safety, NOEL, LOEL Exposure, Hazard, Risk, risk assessment and management Toxicokinetic Molecular aspects of Toxicity: structure-activity relationship; cytotoxicity; carcinogenesis; teratology Toxicology of the central nervous system: Neuronopathy, Axonopathy, Synaptopathy, Myelinopathy. Neurotoxicity and the neurotransmission: excitotoxicity. Toxins and vesicular release Heavy Metals Toxicity Toxicity of biotechnological drugs Marine Biotoxins RECOMMENDED READING/BIBLIOGRAPHY Casarett & Doull. Elementi di Tossicologia Edizione italiana a cura di Patrizia Hrelia e Giorgio Cantelli Forti Casa Editrice Ambrosiana Notes of Lessons TEACHERS AND EXAM BOARD CHIARA CERVETTO Ricevimento: By appointment Exam Board CHIARA CERVETTO (President) MANUELA MARCOLI ANNA MARIA PITTALUGA LESSONS LESSONS START I semester Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION To assess student’s achievement of learning, the examination will be an oral exam (30 minutes), always in presence of the Commission consisting of at least of two professors (or sometime in presence of a professor and an expert subject designated by the CCS). ASSESSMENT METHODS The Commission will verify the achievement of learning outcome with high accuracy. During the examination, the Commission will collect information about the knowledge of the topics and their understating, the communication skills as well as the connection and reasoning within topics of the course. When the educational objectives will be not achieved, the student will be invited to verify better the knowledge and to use supplemental explanations contacting the professor. Exam schedule Data appello Orario Luogo Degree type Note 24/01/2019 09:30 GENOVA Laboratorio 14/02/2019 09:30 GENOVA Laboratorio 14/06/2019 09:30 GENOVA Laboratorio 28/06/2019 09:30 GENOVA Laboratorio 19/07/2019 09:30 GENOVA Laboratorio 11/09/2019 09:30 GENOVA Laboratorio 26/09/2019 09:30 GENOVA Laboratorio