CODE 62662 ACADEMIC YEAR 2020/2021 CREDITS 7 cfu anno 2 ODONTOIATRIA E PROTESI DENTARIA 8746 (LM-46) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: School of Dental Medicine 8746 (coorte 2019/2020) BIOCHEMISTRY 62658 2019 PHYSIOLOGY 62661 2019 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: School of Dental Medicine 8746 (coorte 2019/2020) MEDICAL SCIENCE I 67082 School of Dental Medicine 8746 (coorte 2019/2020) PHARMACOLOGY 67210 School of Dental Medicine 8746 (coorte 2019/2020) DENTAL PATHOLOGY 67213 School of Dental Medicine 8746 (coorte 2019/2020) MEDICAL IMAGING FOR RADIOTHERAPY 67211 School of Dental Medicine 8746 (coorte 2019/2020) PATHOLOGICAL ANATOMY 67208 TEACHING MATERIALS AULAWEB OVERVIEW Pathology is the study (logos) of suffering (pathos). It is a bridging discipline connecting basic science and clinical practice, and is devoted to the study of the structural and functional changes in cells, tissues and organs that underlie disease. Through molecular, microbiological, immunological and morphological studies, General Pathology investigates the different causes of disease and their pathogenic mechanisms to favor the development of effective therapies. AIMS AND CONTENT LEARNING OUTCOMES The learning outcome is the knowledge the main responses of tissues to injuries mediated by exogenous or endogenous agents. TEACHING METHODS Lectures, with any possible dialectic interaction with students In case of sanitary emergency, lessons will switch to remote learning SYLLABUS/CONTENT Environmental factors of disease: physical causes (radiation, temperature extremes and mechanical energy); chemical causes. Mechanisms of xenobiotic biotransformation. Cell pathology: adaptation (atrophy/hypertropy, metaplasy, neoplasy) and death (necrosis and apoptosis). Innate immunity: cells and molecules, local and systemic inflammation, acute and chronic, histological variants of inflammation, tissue damage repair and regeneration. Adaptive Immunity: generation, education and function of B and T lymphocytes Type I hypersensitivity Mention of immune system’s diseases (immunodeficiencies, autoimmunity and auto-inflammatory diseases) Mention of Hematopoietic stem cells (HSC) and HSC transplants Mention of Overview of anemia and hemostasis disorders Atherosclerosis and mention of cardiovascular disease and rheumatic fever Oncology: benign and malign neoplasms, the abnormal metabolism of cancer cells, metastasis, local and systemic effects, paraneoplastic syndromes. Epidemiology (risk and prognostic factors). Molecular basis of tumor transformation: oncogenes, oncosuppressors and examples of tumors. Epigenetic mechanisms (methylation, miRNA). Cancer stem cells (CSC), Tumor-associated angiogenesis and tumor microenvironment. Immune responses against cancer, Natural killer cells, tumor escape mechanisms, tumor-associated inflammation. Environmental causes of cancer: physical, chemical and biological carcinogenesis. Optical microscope evaluation of pathologic tissues (different types of inflammation and cancer). RECOMMENDED READING/BIBLIOGRAPHY Robbins & Cotran Pathologic Basis of Disease, Elsevier Abbas & Lichtman Cellular and Molecular Immunology, Elsevier The didactic material is available in pdf format for download (https://www.aulaweb.unige.it). TEACHERS AND EXAM BOARD CRISTINA BOTTINO Ricevimento: By appointment Email: Cristina.Bottino@unige.it ROBERTA RICCIARELLI Ricevimento: By appointment by email: ricciarelli@medicina.unige.it Exam Board CRISTINA BOTTINO (President) ROBERTA RICCIARELLI (President) LESSONS LESSONS START 2nd semester, 2nd year Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral exams. The students are evaluated by two professors about any of the subject of the course program. On line exams in case of sanitary emergency ASSESSMENT METHODS The oral examination consists in several questions, starting from more general questions to more precise ones, in order to assess the knowledge of the students. Students must know the requested pathogenetic mechanisms and demonstrate the ability to connect different subjects of the program. Exam schedule Data appello Orario Luogo Degree type Note 11/01/2021 09:00 GENOVA Orale 11/01/2021 09:00 GENOVA Orale 12/01/2021 09:00 GENOVA Orale 02/02/2021 09:00 GENOVA Orale 23/02/2021 09:00 GENOVA Orale 08/06/2021 09:00 GENOVA Orale 29/06/2021 09:00 GENOVA Orale 20/07/2021 09:00 GENOVA Orale 07/09/2021 09:00 GENOVA Orale 21/09/2021 09:00 GENOVA Orale 17/12/2021 14:30 GENOVA Orale FURTHER INFORMATION The didactic material is available in pdf format for download (https://www.aulaweb.unige.it) Students can contact the teachers by mail (information, appointment)