CODE 98818 ACADEMIC YEAR 2021/2022 CREDITS 2.5 cfu anno 2 MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY 10598 (LM-9) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/14 LANGUAGE English TEACHING LOCATION GENOVA SEMESTER 2° Semester TEACHING MATERIALS AULAWEB OVERVIEW Conditions affecting perception, mood, emotions and ideation represents, in their most severe forms, a major cause of distress and inability worldwide. Starting from the mid XX century, pharmacological research has achieved significant advancements in the therapy of these disorders either in terms of disease modification either control of symptoms. Pharmacological control of most symptoms of psychiatric disorders is produced by restoring the neurochemical unbalance that underlies these diseases, indicating neurotransmitter release and receptor modulation as major targets for present and future neuropharmacology Of particular relevance for students, pharmacological characterization of the mechanisms underlying neurotransmitter release, receptor modulation and neuronal plasticity provides a significant contribution to the comprehension of anatomical and neurochemical dynamics that govern the functioning of central and peripheral nerve systems. AIMS AND CONTENT LEARNING OUTCOMES The aim of the course is to provide the students with knowledge about the main classes of drugs active on the central nervous system. The course will be focused to study the main pharmacological strategies used to modulate the neurochemical and behavioral responses to affect the pathogenetic mechanisms of the main CNS diseases. AIMS AND LEARNING OUTCOMES The student will be able to understand the mechanisms of action through which drugs affect synaptic transmission and the role of receptor modulation in such as effect. Morever, the student will be aware of the current cellular and molecular alterations responsible of principal CNS diseases and how the drugs can interfere with thes epathogenetic mechanisms. PREREQUISITES none TEACHING METHODS Teaching will be performed by frontal lessons in English SYLLABUS/CONTENT 1) Mechanism of pain trasmission to the CNS, antalgic drugs (opioids, adjuvant drugs) 2) Anti-parkinson drugs 3) Cannabinoids 4) antiepileptic drugs 5) anxiolytic and hypnotic drugs 6) antipsychotic drugs 7) antidepressant drugs RECOMMENDED READING/BIBLIOGRAPHY F. Clementi, G. Fumagalli. Farmacologia generale e molecolare. (Quarta Edizione) UTET. The slides used during the frontal lessons will be available to the students via Aulaweb. TEACHERS AND EXAM BOARD TULLIO FLORIO Ricevimento: All the days, after appointament (tel 010-3538806, e-mail: tullio.florio@unige.it) in the office at the ex-Institute ph Pharmacology, viale Benedetto XV num 2. STEFANO THELLUNG DE COURTELARY Ricevimento: As long as the COVID19 emergency will not allow personal receptions, students will be received on the platform microsoft teams code 3f12f6. Student reception will be held at ex inst. of Pharmacology ground floor. Viale Benedetto XV, 2 phone +39 0103538884. cell 3291484399. email: stefano.thellung@unige.it LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The exam will be performed as an interview in English ASSESSMENT METHODS The students' acquisition of the Neuropharmacology notions will be evaluated through an interview in English. The student will have to demonstrate the knowledge of the molecular bases of the CNS diseases and how the drugs intefere with.
